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<p>Dopamine has been widely used as a first-line cardiovascular agent in neonatal intensive care units (NICUs) for the management of hypotension and circulatory support. While its effectiveness in increasing blood pressure is established, its potential effects on pulmonary vascular resistance, myocardial function, and overall hemodynamics require further consideration. This review explores the role of dopamine in neonatal hemodynamic management and considers alternative vasoactive agents tailored to specific pathophysiological conditions. A more individualized, physiology-based approach to cardiovascular support in neonates may help optimize treatment strategies.</p>

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Physiology-guided vasoactive therapy in neonates: rethinking dopamine as first-line

  • 期刊论文

  • 发表日期：

    2025年9月4日

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  • Audrey Hébert,
  • Satyan Lakshminrusimha,
  • Danielle R. Rios,
  • Shazia Bhombal,
  • Shiran Sara Moore,
  • Stephanie Ford,
  • Gabriel Altit

摘要

Dopamine has been widely used as a first-line cardiovascular agent in neonatal intensive care units (NICUs) for the management of hypotension and circulatory support. While its effectiveness in increasing blood pressure is established, its potential effects on pulmonary vascular resistance, myocardial function, and overall hemodynamics require further consideration. This review explores the role of dopamine in neonatal hemodynamic management and considers alternative vasoactive agents tailored to specific pathophysiological conditions. A more individualized, physiology-based approach to cardiovascular support in neonates may help optimize treatment strategies.