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Objective <p>To describe infection epidemiology and measure antibiotic utilization among a large cohort of newborns with congenital diaphragmatic hernia (CDH).</p> Study design <p>Retrospective observational study including inborn newborns with CDH at a level IV referral center (free-standing children’s hospital with special delivery unit) and two associated level III birth centers who underwent active care and survived to NICU admission, born 1/2013-11/2022 with available disposition.</p> Results <p>Of 381 newborns with CDH who were admitted to the NICU, 370 (97.1%) received antibiotics. There were 137 (36.1%) newborns with a positive bacterial culture from any source; 78/381 (20.4%) had a positive culture from blood, urine, or spinal fluid.</p> Conclusion <p>Nearly all newborns with CDH at our center received antibiotics during their hospitalization, but the majority did not have a positive bacterial culture result, indicating opportunities exist for antibiotic stewardship among this population.</p>

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Antibiotic exposure and infection epidemiology among newborns with congenital diaphragmatic hernia

  • 期刊论文

  • 发表日期：

    2025年8月18日

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  • Sabrina J. Flohr,
  • Leny Mathew,
  • Holly L. Hedrick,
  • Natalie E. Rintoul,
  • Talene A. Metjian,
  • Sanjeev K. Swami,
  • Jeffrey S. Gerber,
  • Alexandra K. Medoro,
  • Dustin D. Flannery

摘要

Objective

To describe infection epidemiology and measure antibiotic utilization among a large cohort of newborns with congenital diaphragmatic hernia (CDH).

Study design

Retrospective observational study including inborn newborns with CDH at a level IV referral center (free-standing children’s hospital with special delivery unit) and two associated level III birth centers who underwent active care and survived to NICU admission, born 1/2013-11/2022 with available disposition.

Results

Of 381 newborns with CDH who were admitted to the NICU, 370 (97.1%) received antibiotics. There were 137 (36.1%) newborns with a positive bacterial culture from any source; 78/381 (20.4%) had a positive culture from blood, urine, or spinal fluid.

Conclusion

Nearly all newborns with CDH at our center received antibiotics during their hospitalization, but the majority did not have a positive bacterial culture result, indicating opportunities exist for antibiotic stewardship among this population.