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Objective <p>Evaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks’ gestation.</p> Study design <p>Retrospective, multi-center, observational study.</p> Results: <p>One hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (<i>n</i> = 23, 60%); LP and ventricular access device (VAD) only (<i>n</i> = 6, 16%); LP, VAD, ventricular-peritoneal shunt (<i>n</i> = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (<i>p</i> &gt; 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (<i>p</i> &lt; 0.05).</p> Conclusion <p>Initiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.</p>

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Implementation of an early intervention strategy for post hemorrhagic ventricular dilatation in preterm infants

  • 期刊论文

  • 发表日期：

    2025年7月25日

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  • Diane Wilson,
  • Sara Breitbart,
  • Lee DiFonzo,
  • Edmond Kelly,
  • Yenge Diambomba,
  • Dilkash Kajal,
  • Kamini Raghuram,
  • Sabrina Wong,
  • Eugene Ng,
  • Paige Church,
  • Elizabeth Asztalos,
  • Phyllis Glanc,
  • Mehmet Cizmeci,
  • Rosanna Pais,
  • Jeffery Traubici,
  • Lara M. Leijser,
  • Steven P. Miller,
  • Abhaya V. Kulkarni,
  • Linh G. Ly

摘要

Objective

Evaluate earlier intervention on short- and longer-term outcomes in preterm infants with post-hemorrhagic ventricular dilatation (PHVD) born at ≤32 weeks’ gestation.

Study design

Retrospective, multi-center, observational study.

Results:

One hundred patients met eligibility criteria. Of 70 survivors, PHVD resolved spontaneously in 32 (46%). The 38 infants needing intervention were managed with: lumbar puncture (LP) alone (n = 23, 60%); LP and ventricular access device (VAD) only (n = 6, 16%); LP, VAD, ventricular-peritoneal shunt (n = 9, 24%). There were no differences in incidence of cerebral palsy or Bayley Scales of Infant and Toddler Development (BSID-III) composite score between the intervention and non-intervention group (p > 0.5). Neurosurgical intervention was initiated at smaller ventricle size and BSID-III scores improved significantly compared to a historical cohort with late intervention, (p < 0.05).

Conclusion

Initiation of early intervention for PHVD was feasible and was associated with improved neurodevelopmental outcomes compared to late intervention.