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Objectives <p>To evaluate the association between an exclusive human milk diet (EHMD) and motor function impairment at three years of corrected age among infants born before 32 weeks of gestation.</p> Methods <p>We conducted a retrospective study between 2018 and 2021. We assigned to the EHMD group infants who received an EHMD for ≥75% of the days between the first day of diet fortification and 33 6/7 weeks postmenstrual age. We used inverse propensity scores to balance potential confounders and developed a mixed-effects logistic regression model to assess the association.</p> Results <p>After adjusting for demographics and morbidities, an EHMD was associated with a reduced risk of motor function impairment, with an odds ratio of 0.74 (95% CI: 0.56–0.98, <i>p</i> = 0.036).</p> Conclusions <p>An EHMD is associated with a decrease in the odds of early childhood motor function impairment among infants born before 32 weeks of gestation.</p>

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Exclusive human milk diet is associated with lower risk of motor function impairment at three years of corrected age

  • 期刊论文

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  • 发表日期：

    2025年4月21日

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  • Fu-Sheng Chou,
  • Jing Zhang,
  • Maria Fe B. Villosis,
  • Ashwini Lakshmanan

摘要

Objectives

To evaluate the association between an exclusive human milk diet (EHMD) and motor function impairment at three years of corrected age among infants born before 32 weeks of gestation.

Methods

We conducted a retrospective study between 2018 and 2021. We assigned to the EHMD group infants who received an EHMD for ≥75% of the days between the first day of diet fortification and 33 6/7 weeks postmenstrual age. We used inverse propensity scores to balance potential confounders and developed a mixed-effects logistic regression model to assess the association.

Results

After adjusting for demographics and morbidities, an EHMD was associated with a reduced risk of motor function impairment, with an odds ratio of 0.74 (95% CI: 0.56–0.98, p = 0.036).

Conclusions

An EHMD is associated with a decrease in the odds of early childhood motor function impairment among infants born before 32 weeks of gestation.