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Objective <p>To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC).</p> Design <p>Pilot randomized controlled trial.</p> Methods <p>Neonates with REDF (<i>n</i> = 52) were randomized to start feeds at 6 h (<i>n</i> = 26) or 24 h (<i>n</i> = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay.</p> Results <p>FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar.</p> Conclusions <p>Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC.</p> Trial registration <p>Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.</p>

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Initiation of enteral feeding as per current protocol (at 24 h) versus as per clinical status (from 6 h onwards) in neonates born with antenatal reversed end diastolic flow (REDF) in the umbilical artery Doppler: a pilot randomized controlled trial

  • 期刊论文

  • 发表日期：

    2025年4月6日

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  • Rishi Kathuria,
  • Kanya Mukhopadhyay

摘要

Objective

To compare the effects of initiating feeds at 24 h versus at 6 h in neonates with reversed end-diastolic flow (REDF) and determine the incidence of feed intolerance (FI) and necrotizing enterocolitis (NEC).

Design

Pilot randomized controlled trial.

Methods

Neonates with REDF (n = 52) were randomized to start feeds at 6 h (n = 26) or 24 h (n = 26) to assess FI, NEC, time to full feeds, sepsis, mortality, weight and gestation at discharge, and hospital stay.

Results

FI was observed in 14 (54%) neonates in 6 h group and 17 (65%) in 24 h group, with comparable NEC rates. Neonates in the 6 h group achieved full feeds faster (8 vs. 11 days) and had shorter hospital stay (17 vs. 32 days). Death and sepsis rates were similar.

Conclusions

Feed initiation at 6 h in REDF neonates did not increase the risk of FI or NEC.

Trial registration

Clinical trial registry of India (CTRI/2023/02/050025); 23/02/2023.