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Background <p>Positive pressure ventilation (PPV) with high variability in delivered tidal volume (TV) may cause volutrauma. We aimed to assess feasibility of providing Volume Targeted-Positive Pressure Ventilation (VT-PPV) to preterm infants receiving invasive mechanical ventilation via endotracheal tube in the delivery room (DR).</p> Design/methods <p>TV measurements were available from a respiratory function monitor (RFM) to adjust peak inspiratory pressures to target TV of 4–6 ml/kg for participants in the intervention cohort (VT-PPV). This data was compared with a historic cohort (HC), where providers were blinded from RFM measurements.</p> Results <p>With VT-PPV, goal TV (4–6 ml/kg) was provided 40.1% of times (vs. HC:23.6%, <i>p</i> = 0.002); low TV (&lt;4 ml/kg) was provided 8.6% of times (vs. HC:28.1%, <i>p</i> ≤ 0.001). There was no difference in higher TV provided in the two cohorts.</p> Conclusion: <p>Providing VT-PPV in intubated preterm infants may be feasible in DR and may result in increased number of breaths in target range.</p>

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Feasibility of volume targeted- positive pressure ventilation for preterm infants requiring invasive ventilation in the delivery room

  • 期刊论文

  • 发表日期：

    2025年3月27日

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  • Ruben Vaidya,
  • Paul Visintainer,
  • Rachana Singh

摘要

Background

Positive pressure ventilation (PPV) with high variability in delivered tidal volume (TV) may cause volutrauma. We aimed to assess feasibility of providing Volume Targeted-Positive Pressure Ventilation (VT-PPV) to preterm infants receiving invasive mechanical ventilation via endotracheal tube in the delivery room (DR).

Design/methods

TV measurements were available from a respiratory function monitor (RFM) to adjust peak inspiratory pressures to target TV of 4–6 ml/kg for participants in the intervention cohort (VT-PPV). This data was compared with a historic cohort (HC), where providers were blinded from RFM measurements.

Results

With VT-PPV, goal TV (4–6 ml/kg) was provided 40.1% of times (vs. HC:23.6%, p = 0.002); low TV (<4 ml/kg) was provided 8.6% of times (vs. HC:28.1%, p ≤ 0.001). There was no difference in higher TV provided in the two cohorts.

Conclusion:

Providing VT-PPV in intubated preterm infants may be feasible in DR and may result in increased number of breaths in target range.