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Objective <p>To evaluate the longitudinal changes of IL-1α, IL-1β, and IL-1Ra in extremely preterm infants and investigate the dynamic association with bronchopulmonary dysplasia (BPD).</p> Methods <p>Plasma samples were collected from extremely preterm infants at postnatal day (PD) 7,28 and PMA 36 weeks. IL-1 cytokines concentrations were measured by Bio-Plex Pro (human cytokine panel). Univariate and multivariate logistic regression analysis were conducted to explore the association between the cytokines and BPD.</p> Results <p>BPD infants exhibited significantly higher concentrations of IL-1α (10.75 vs. 8.18 pg/ml, <i>p</i> = 0.026), IL-1β (2.00 vs. 1.50 pg/ml, <i>p</i> = 0.046), and IL-1Ra (878.50 vs. 262.40 pg/ml, <i>p</i> = 0.011) compared to non-BPD infants at PD 28. Higher IL-1α concentration (≥8.09 pg/ml) at PD 28 was independently associated with BPD development (OR: 8.272, 95% CI: 1.127–60.705, <i>p</i> = 0.038).</p> Conclusions <p>Increased IL-1α concentrations at PD 28 were independently associated with an increased risk of BPD.</p>

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Dynamic association between plasma interleukin-1 family concentrations and bronchopulmonary dysplasia in extremely premature infants

  • 期刊论文

  • 发表日期：

    2025年3月30日

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  • Qingling Li,
  • Cuihui Li,
  • Yunbei Rao,
  • Dongshan Han,
  • Xuan Wang,
  • Lingling Yang,
  • Yiran Chen,
  • Chuanzhong Yang,
  • Xueyu Chen

摘要

Objective

To evaluate the longitudinal changes of IL-1α, IL-1β, and IL-1Ra in extremely preterm infants and investigate the dynamic association with bronchopulmonary dysplasia (BPD).

Methods

Plasma samples were collected from extremely preterm infants at postnatal day (PD) 7,28 and PMA 36 weeks. IL-1 cytokines concentrations were measured by Bio-Plex Pro (human cytokine panel). Univariate and multivariate logistic regression analysis were conducted to explore the association between the cytokines and BPD.

Results

BPD infants exhibited significantly higher concentrations of IL-1α (10.75 vs. 8.18 pg/ml, p = 0.026), IL-1β (2.00 vs. 1.50 pg/ml, p = 0.046), and IL-1Ra (878.50 vs. 262.40 pg/ml, p = 0.011) compared to non-BPD infants at PD 28. Higher IL-1α concentration (≥8.09 pg/ml) at PD 28 was independently associated with BPD development (OR: 8.272, 95% CI: 1.127–60.705, p = 0.038).

Conclusions

Increased IL-1α concentrations at PD 28 were independently associated with an increased risk of BPD.