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Objective <p>To evaluate feasibility and efficacy of early exclusive enteral feeding (EEEF) in reducing time to achieve full enteral feeds.</p> Methods <p>A pragmatic randomized controlled trial of infants born at 30<sup>0/7</sup>–33<sup>6/7</sup> weeks gestation. Infants were randomly assigned to receive EEEF (60–80 mL/kg/day) or conventional feeding (20–30 mL/kg/day) with intravenous fluids after birth. Feed volumes were increased by 20–30 mL/kg/day. Primary outcome was time to reach full enteral feeds.</p> Results <p>Seventy infants were enrolled. Infants in EEEF group achieved full feeds sooner [Mean difference (MD) −1.2 (95%CI −1.8, −0.7)], required fewer hours of parenteral nutrition [0 (IQR 0, 19) vs. 91 (IQR 48, 132) hours, <i>P</i> &lt; 0.001], had less need for central venous access (11.4% vs. 37.1%, <i>P</i> = 0.01) and had shorter hospital stays [MD −6.6 (95%CI −12.9, −0.2) days].</p> Conclusion <p>Early exclusive enteral feeding in 30<sup>0/7</sup>–33<sup>6/7</sup> weeks gestation infants is feasible and reduces time required to achieve full enteral feeds and length of hospital stay.</p> Trial Registration <p>ClinicalTrials.gov: NCT03708068</p>

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Early exclusive enteral feeding in 30–33 weeks gestation infants: a randomized controlled trial

  • 期刊论文

  • 发表日期：

    2025年2月2日

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  • Belal N. Alshaikh,
  • Ossama Hassan,
  • Wissam Alburaki,
  • Dinesh Dharel,
  • Adel Elsharkawy,
  • Nalini Singal,
  • Kamran Yusuf,
  • Essa Al Awad

摘要

Objective

To evaluate feasibility and efficacy of early exclusive enteral feeding (EEEF) in reducing time to achieve full enteral feeds.

Methods

A pragmatic randomized controlled trial of infants born at 300/7–336/7 weeks gestation. Infants were randomly assigned to receive EEEF (60–80 mL/kg/day) or conventional feeding (20–30 mL/kg/day) with intravenous fluids after birth. Feed volumes were increased by 20–30 mL/kg/day. Primary outcome was time to reach full enteral feeds.

Results

Seventy infants were enrolled. Infants in EEEF group achieved full feeds sooner [Mean difference (MD) −1.2 (95%CI −1.8, −0.7)], required fewer hours of parenteral nutrition [0 (IQR 0, 19) vs. 91 (IQR 48, 132) hours, P < 0.001], had less need for central venous access (11.4% vs. 37.1%, P = 0.01) and had shorter hospital stays [MD −6.6 (95%CI −12.9, −0.2) days].

Conclusion

Early exclusive enteral feeding in 300/7–336/7 weeks gestation infants is feasible and reduces time required to achieve full enteral feeds and length of hospital stay.

Trial Registration

ClinicalTrials.gov: NCT03708068