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Objective <p>Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE).</p> Study design <p>Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010–2015) and Epoch 2 (2016–2019). Risk ratios (RR) for induced hypothermia (IH) in each epoch and their outcomes were calculated using log-linear regression.</p> Results <p>In this cohort, 4779 infants with HIE were identified. Incidence of HIE in California increased yearly from 0.5/1000 California births to a peak of 1.5/1000 births in 2018. The use of IH in infants with mild HIE increased in Epoch 2 compared to Epoch 1. There was no significant difference in outcomes between epochs for infants with mild HIE that received IH including no difference in neonatal seizures.</p> Conclusion <p>Significantly more infants with mild HIE received IH since 2015 in California, but no significant difference in outcomes.</p>

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Changes in the treatment and outcomes of different severities of neonatal hypoxic ischemic encephalopathy in California: a retrospective cohort study

  • 期刊论文

  • 发表日期：

    2025年1月26日

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  • Carolyn Fall,
  • Rebecca J. Baer,
  • Henry C. Lee,
  • Gretchen Bandoli,
  • Christina D. Chambers

摘要

Objective

Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE).

Study design

Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010–2015) and Epoch 2 (2016–2019). Risk ratios (RR) for induced hypothermia (IH) in each epoch and their outcomes were calculated using log-linear regression.

Results

In this cohort, 4779 infants with HIE were identified. Incidence of HIE in California increased yearly from 0.5/1000 California births to a peak of 1.5/1000 births in 2018. The use of IH in infants with mild HIE increased in Epoch 2 compared to Epoch 1. There was no significant difference in outcomes between epochs for infants with mild HIE that received IH including no difference in neonatal seizures.

Conclusion

Significantly more infants with mild HIE received IH since 2015 in California, but no significant difference in outcomes.