Cerebral magnetic resonance spectroscopy – insights into preterm brain injury

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2024年11月28日

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Magdalena Zasada,
Paulina Karcz,
Marta Olszewska,
Aleksandra Kowalik,
Wojciech Zasada,
Izabela Herman-Sucharska,
Przemko Kwinta

摘要

Objective

Magnetic resonance spectroscopy (¹H-MRS) may provide clinically relevant data regarding metabolic processes that govern the course of preterm brain injury.

Study design

46 very preterm infants (VP) were evaluated by magnetic resonance imaging and ¹H-MRS at term-equivalent age. Brain injury was assessed according to the Kidokoro scale. Moreover, 17 term-born infants with hypoxic-ischemic encephalopathy (HIE) were scanned. The metabolic profile of the central nervous system was obtained from the bilateral thalamus.

Result

The Lipids/Creatine, Choline/Creatine, N-acetyl aspartate/Choline, Lactate/N-acetyl aspartate, and Lactate/Creatine ratios differed between VP infants with moderate+severe brain damage and those without brain injury. Moreover, VP infants with moderate+severe brain damage had higher Lactate/ N-acetyl aspartate and Lactate/Creatine ratios than HIE group.

Conclusion

There were significant differences in the cerebral metabolite profile at TEA between VP infants with and without brain injury. The ¹H-MRS profile of VP infants with moderate+severe brain damage may reflect profound chronic metabolic alterations.