Implementation of an EOS calculator-based protocol decreased infant antibiotic exposure in chorioamnionitis without correlation with placental histopathology

To determine the impact of the Early Onset Sepsis (EOS) calculator on antibiotic exposure in infants born to mothers with clinical chorioamnionitis and correlate EOS calculator-guided recommendations with placental histopathology.

Retrospective observational study comparing infants ≥ 36 weeks gestation exposed to maternal clinical chorioamnionitis admitted to the neonatal intensive care unit (NICU) before (Group 1, n = 69) and after (Group 2, n = 139) implementation of an EOS calculator protocol for chorioamnionitis. Infant antibiotic exposure and placental pathology were reviewed. Comparisons were made using Mann-Whitney and chi-square tests.

There was a statistically significant decrease in antibiotic exposure from Group 1 to Group 2 (p < 0.001) with no EOS cases missed. No correlation was found between EOS calculator-based treatment and participant placental histopathology (p = 0.966).

Implementation of an EOS calculator protocol specific to our study population reduced antibiotic exposure. No correlations were found between EOS calculator-based antibiotic treatment and histological chorioamnionitis.