Post-procedure pain in preterm neonates undergoing retinopathy of prematurity (ROP) screening: a prospective cohort study

期刊论文
发表日期：

2024年11月21日

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Raman Singla,
Ankit Verma,
Vivek Kumar,
Purna Chandra,
Parijat Chandra,
Anu Thukral,
M. Jeeva Sankar,
Ramesh Agarwal,
Ashok Kumar Deorari

摘要

Objective

To evaluate the pain intensity in preterm infants during 48 h post retinopathy of prematurity (ROP) screening by binocular fundoscopy.

Design

Prospective cohort study.

Settings

Level-III-NICU in India.

Participants

83 Neonates undergoing first ROP screening.

Main outcome measures

Pain assessment using the premature infant pain profile-revised (PIPP-R) score at baseline and 5 min, 30 min, 6 h, 24 h, and 48 h post-procedure.

Results

The mean gestation and birth weight was 29.8 (2.3) weeks and 1256 (344)g respectively. The median (IQR) PIPP-R score at baseline was 0 which significantly increased to 10.5 (8,12.5) 5 min (immediately) after the procedure. At 30 min and 6 h, scores were 7 (5,8) and 4.5 (3,5.5) respectively. After 24 h and 48 h, it decreased to 3 (0,5) and 0 (0,4.5) respectively. Nearly 59% (95%CI:40%–83%) of neonates had severe pain (PIPP-R score > 12) immediately after procedure.

Conclusion

A majority of neonates experience severe pain immediately after ROP screening, and mild-moderate pain continues for 6 h. Hence, an additional pharmacological agent should be considered for reducing neonatal pain.