The association of the room air challenge with long-term outcomes in extremely preterm infants

期刊论文
发表日期：

2024年8月3日

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Samia Aleem,
Barbara T. Do,
Marie G. Gantz,
Anna Maria Hibbs,
Erik A. Jensen,
C. Michael Cotten,
William F. Malcolm,
Alan H. Jobe,
Rachel G. Greenberg

摘要

Objective

Evaluate the association between results of the room air (RA) challenge and death, respiratory morbidity, and neurodevelopmental impairment (NDI) at 2 years' corrected age.

Study design

Cohort study of infants born <27 weeks’ gestational age who underwent a RA challenge to determine BPD diagnosis at 36 weeks postmenstrual age.

Results

Of 1022 infants eligible for the RA challenge, 554 underwent testing and 223 passed. Test result was not associated with death or serious respiratory morbidities [adjusted relative risk (aRR) 1.01, 95% confidence interval (CI) 0.65–1.56] or death or moderate/severe NDI (aRR 1.06, 95% CI 0.81–1.39) at 2 years.

Conclusion

Results of the RA challenge were not associated with differences in respiratory or neurodevelopmental morbidity at 2 years, suggesting the RA challenge does not add prognostic value in contemporary extremely preterm infants.

ClinicalTrials.gov ID

Generic Database: NCT00063063.