Surfactant treatment at birth in a contemporary cohort of preterm infants with bronchopulmonary dysplasia

期刊论文
发表日期：

2024年7月17日

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Clifford Mueller,
Edward G. Shepherd,
Matthew J. Kielt,
Sara Conroy,
Erik A. Jensen,
Nicolas A. Bamat,
Howard Panitch,
Jon Levin,
Milenka Guaman Cuevas,
William Truog,
Steven H. Abman,
Leif D. Nelin,
Milenka Guaman Cuevas

摘要

Objective

Initial surfactant studies demonstrated improvements in survival and need for respiratory support. However, as the use of non-invasive respiratory support has increased the use of surfactant has decreased. We examined in a contemporary cohort of BPD patients if surfactant use was associated with BPD severity.

Study design

An observational study using data from the BPD Collaborative Registry.

Results

971 infants with BPD met entry criteria, 864 (89%) had received surfactant in the first 72 h of life (SURF) and the remainder had not (no surfactant). There was an association between SURF and BPD grade, with a greater likelihood of grade 3 BPD in infants who received surfactant in the DR or who had 2 or more doses.

Conclusions

We speculate that the use of surfactant in the DR and use of multiple doses reflect the impact of perinatal factors beyond immaturity alone that increase the risk for grade 3 BPD.