Antenatal exposure to magnesium sulfate and neonatal outcomes in very low birth weight infants: a multicenter study

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发表日期：

2024年6月7日

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Catalina Vaz Ferreira,
Jose Caro,
Luis Villarroel,
Sergio Muñoz,
Patricia Alvarez,
Gerardo Flores,
Tamara Herrera,
Alberto Toso,
Paulina Toso,
Jose L. Tapia,
Catalina Vaz Ferreira

摘要

Objective

To explore the association between antenatal magnesium sulfate (MgSO₄), mortality and incidence of intraventricular hemorrhage (IVH) in very low birth weight (VLBW) infants.

Study design

Retrospective, cohort study of infants <32 weeks’ GA born at centers of NEOCOSUR Network between January 2015 and December 2020. Subjects were categorized as exposed vs non-exposed to antenatal MgSO₄. Primary outcomes were death, incidence of severe IVH (Grade III-IV) and severe IVH/death. Secondary outcomes included relevant morbidities.

Results

7418 VLBW infants were eligible. Antenatal MgSO₄ was associated with a significantly decreased death rate after admission (aOR 0.67 [95% CI, 0.49–0.94]) and severe IVH/ death (aOR 0.68 [95% CI, 0.50–0.93]). No significant reduction in severe IVH was observed (aOR 1.11 [95% CI, 0.72–1.71]). No differences between groups were observed in rates of morbidities.

Conclusion

Antenatal MgSO₄ was associated with a decreased death rate after admission and in severe IVH/ death.