Vitamin K prophylaxis in neonates: comparing two different oral regimens

期刊论文
发表日期：

2024年4月27日

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Daijiro Takahashi,
Naoki Egami,
Masayuki Ochiai,
Taeko Hotta,
Shutaro Suga,
Masataka Ishimura,
Chiharu Kawaguchi,
Takeshi Uchiumi,
Toshiya Nishikubo,
Keiji Nogami,
Kei Goto,
Shouichi Ohga

摘要

Objective

This prospective study compared PIVKA-II and PT-INR levels in infants who received two vitamin K (VK) prophylactic regimens.

Methods

A single institution administered 119 healthy newborns 2 mg of VK syrup. Infants were assigned to a 3-time regimen (n = 56) with VK at birth, five days (5D), and 1-month-old (1 M), or a 13-time regimen (n = 63) with VK at birth, 5D, and then weekly for 11 weeks.

Results

The 13-time regimen significantly lowered PIVKA-II and reduced PT-INR at 1 M in both breastfed (PIVKA-II: 18–16 mAU/mL, p = 0.02; PT-INR: 1.37–1.13, p < 0.01) and formula-fed infants (PIVKA-II: 18–15 mAU/mL, p = 0.01; PT-INR: 1.54–1.24, p < 0.01), compared to baseline measurements taken at 5D. The 3-time regimen did not significantly alter PIVKA-II levels and only improved PT-INR (2.00–1.50, p < 0.01) in formula-fed infants.

Conclusion

The 13-time VK regimen significantly enhanced coagulation profiles more effectively than the 3-time regimen.