Association between early echocardiography screening of low systemic blood flow and intraventricular hemorrhage in preterm infants: a multicenter cohort study

期刊论文
发表日期：

2024年4月25日

查看全文

Sandra Terroba-Seara,
Ignacio Oulego-Erroz,
Daniel Palanca-Arias,
Zenaida Galve-Pradel,
Sara Delgado-Nicolás,
Alicia Pérez-Pérez,
Jorge Rodríguez-Ozcoidi,
Ana Lavilla-Oíz,
María Carmen Bravo,
Leticia La Banda-Montalvo,
Paula Méndez-Abad,
Pamela Zafra-Rodríguez,
Lorena Rodeño-Fernández,
Jon Montero-Gato,
Carmen Bustamante-Hervás,
Cristina Vega-Del-Val,
Javier Rodríguez-Fanjul,
Juan Mayordomo-Colunga,
Iosune Alegría-Echauri,
Andrea Pérez-Álvarez

摘要

Objective

To determine whether early echocardiography screening of low systemic blood flow reduces intraventricular hemorrhage in preterm infants.

Study design

Prospective multicenter study in preterm infants below 33 weeks of gestational age at nine neonatal units. Five units performed early echocardiography screening for low systemic blood flow and guided clinical management (exposure group) and 4 units did not (control group). Our main outcome was ≥grade II intraventricular hemorrhage or death within the first 7 days of life. The main analysis used the inverse probability of treatment weighting.

Results

Three hundred and thirty-two preterm infants (131 in the exposure group and 201 in the control group) were included. Exposure to early echocardiography screening was associated with a significant reduction in ≥grade II intraventricular hemorrhage or early death [odds ratio 0.285 (95% CI: 0.133–0.611); p = 0.001].

Conclusions

Early echocardiography screening for low systemic blood flow may reduce the incidence of intraventricular hemorrhage in preterm infants.