Association of maternal pre-pregnancy or first trimester body mass index with neurodevelopmental impairment or death in extremely low gestational age neonates

期刊论文
发表日期：

2024年2月23日

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Sanjay Chawla,
Abbot R. Laptook,
Emily A. Smith,
Sylvia Tan,
Girija Natarajan,
Myra H. Wyckoff,
Rachel G. Greenberg,
Namasivayam Ambalavanan,
Edward F. Bell,
Krisa P. Van Meurs,
Susan R. Hintz,
Betty R. Vohr,
Erika F. Werner,
Abhik Das,
Seetha Shankaran,
Waldemar A. Carlo,
Anna Maria Hibbs,
Stephanie Merhar,
C. Michael Cotten,
Ravi M. Patel,
Tarah T. Colaizy,
Aaron Hamvas,
Abhay J. Bhatt,
Janell Fuller,
Sara DeMauro,
Anup C. Katheria,
Robin K. Ohls,
Jon E. Tyson

摘要

Objective

To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first-trimester maternal body mass index (BMI).

Methods

This retrospective cohort study included extremely preterm infants (gestational age 22^0/7–26^6/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years.

Results

Data on the primary outcome were available for 1208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p = 0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models.

Conclusion

Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.