Association between maternal hypertension and infant neurodevelopment in extremely preterm infants

期刊论文
发表日期：

2024年1月29日

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Wael A. Abdelmageed,
Anie Lapointe,
Richard Brown,
Andreea Gorgos,
Thuy Mai Luu,
Marc Beltempo,
Gabriel Altit,
Natalie Dayan

摘要

Objective

To examine the association between maternal hypertension during pregnancy and neurodevelopmental impairment (NDI) at 24 months post-menstrual age in extremely preterm infants.

Study design

Using data from two tertiary neonatal units (2011–2017) for infants born at 23 + 0 to 28 + 6 weeks, we investigated outcomes of NDI related to maternal hypertension and small-for-gestational-age (SGA) status.

Results

Of 1019 pre-term infants, 647 had complete data and were included in the analysis. Ninety-six (15%) had maternal hypertension exposure; 25 (4%) were also SGA. Infants with maternal hypertension showed a higher odds of any NDI (aOR: 2.29, 95% CI = 1.36–3.87) and significant NDI (aOR: 2.01, 95% CI = 1.02–3.95). The combination of hypertension and SGA further elevated this risk (aOR for any NDI: 4.88, 95% CI = 1.80–13.22; significant NDI: 6.91, 95% CI = 2.50–19.12).

Conclusion

Maternal hypertension during pregnancy elevates the risk of NDI in extremely preterm infants, more so when combined with SGA.