Evaluation of the association between patent ductus arteriosus approach and neurodevelopment in extremely preterm infants

期刊论文
发表日期：

2024年1月26日

查看全文

Soledad Belén Cervera,
Sahar Saeed,
Thuy Mai Luu,
Andrea Gorgos,
Marc Beltempo,
Martine Claveau,
Olga Basso,
Anie Lapointe,
Sophie Tremblay,
Gabriel Altit

摘要

Objective

Assess if unit-level PDA management correlates with neurodevelopmental impairment (NDI) at 18–24 months corrected postnatal age (CPA) in extremely preterm infants.

Study design

Retrospective analysis of infants born at <29 weeks (2014–2017) across two units having distinct PDA strategies. Site 1 utilized an echocardiography-based treatment strategy aiming for accelerated closure (control). Site 2 followed a conservative approach. Primary endpoint: NDI, characterized by cerebral palsy, any Bayley-III composite score <85, sensorineural/mixed hearing loss, or at least unilateral visual impairment.

Results

377 infants were evaluated. PDA treatment rates remained unchanged in Site 1 but eventually reached 0% in Site 2. Comparable rates of any/significant NDI were seen across both sites (any NDI: 38% vs 36%; significant NDI: 13% vs 10% for Site 1 and 2, respectively). After adjustments, NDI rates remained similar.

Conclusion

PDA management strategies in extremely preterm newborns showed no significant impact on neurodevelopment outcomes at 18–24 months CPA.