Contemporary definitions of infant growth failure and neurodevelopmental and behavioral outcomes in extremely premature infants at two years of age

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2024年1月9日

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Katie M. Strobel,
Thomas R. Wood,
Gregory C. Valentine,
Kendell R. German,
Semsa Gogcu,
D. Taylor Hendrixson,
Sarah E. Kolnik,
Janessa B. Law,
Dennis E. Mayock,
Bryan A. Comstock,
Patrick J. Heagerty,
Sandra E. Juul

摘要

Background

Associations of 2-year neurodevelopmental and behavioral outcomes with growth trajectories of preterm infants are unknown.

Methods

This secondary analysis of a preterm cohort examined in-hospital and discharge to 2-year changes in anthropometric z-scores. Two-year follow-up included Bayley Scales of Infant Development (BSID-III) and Child Behavior Checklist.

Results

Among 590 infants, adjusted in-hospital growth was not associated with any BSID-III subscale. Occipitofrontal circumference (OFC) growth failure (GF) in-hospital was associated with increased adjusted odds of attention problems (aOR 1.65 [1.03, 2.65]), aggressive behavior (aOR 2.34 [1.12, 4.89]), and attention-deficit-hyperactivity symptoms (aOR 1.86 [1.05, 3.30]). Infants with OFC GF at 2 years had lower adjusted BSID-III language scores (−4.0 [−8.0, −0.1]), increased odds of attention problems (aOR 2.29 [1.11, 4.74]), aggressive behavior (aOR 3.09 [1.00, 9.56]), and externalizing problems (aOR 3.01 [1.07, 8.45]) compared to normal OFC growth cohort.

Conclusion

Infants with OFC GF are at risk for neurodevelopmental and behavioral impairment.

Clinical trial registration

This study is a secondary analysis of pre-existing data from the PENUT Trial Registration: NCT01378273.