<p>Serum placenta growth factor (PIGF), adiponectin, and endothelin-1 (ET-1) were associated with hypertension. However, it remains unclear whether these factors could predict the occurrence and prognosis of hypertensive disorders complicating pregnancy (HDCP). The enrolled pregnant women were classified into different groups according to diagnosis criteria. The demographic and clinical characteristics were compared among different groups. The levels of serum PIGF, adiponectin and ET-1 were determined. The predictive values of serum PIGF, adiponectin, and ET-1 for the occurrence and prognosis of HDCP were assessed using the receiver operating characteristic curve (ROC) analysis. There was a significant difference in systolic blood pressure, diastolic blood pressure, and proteinuria between the HDCP group and the normal pregnancy group. The level of serum PIGF and adiponectin decreased while ET-1 increased in the HDCP group compared to the normal pregnancy group. Furthermore, they had a similar change pattern with the progression of HDCP. The ROC analysis demonstrated that PIGF, adiponectin and ET-1 could effectively predict the occurrence and prognosis of HDCP. Compared to normal pregnant women, serum PIGF and adiponectin gradually decreased while ET-1 gradually increased with the progression of HDCP. Thus, they could effectively predict the occurrence and prognosis of HDCP.</p>