Scholarlink

Background <p>While polycyclic aromatic hydrocarbons (PAHs) and maternal psychological distress (anxiety/depression) are risk factors for adverse birth outcomes, their joint effects remain poorly understood, particularly across different pre-pregnancy BMI categories.</p> Objective <p>To examine the individual and combined effects of prenatal PAHs exposure and maternal psychological distress on birth outcomes, with emphasis on effect modification by pre-pregnancy BMI.</p> Methods <p>In this prospective cohort study, we enrolled 699 pregnant women from two primary hospitals in Hefei, China, from April 2020 through October 2022. Urinary PAHs were assessed using gas chromatography tandem triple quadrupole mass spectrometry (GC-MS/MS). Anxiety and depression symptoms were assessed via Generalized Anxiety Disorder Scale (GAD-7) and Edinburgh Postnatal Depression Scale (EPDS), respectively. Logistic regression and BKMR models were used to explore the individual and combined effects of prenatal PAHs exposure and psychological distress on birth outcomes.</p> Results <p>Logistic regression revealed significant associations between PAHs and anxiety symptoms with adverse birth outcomes. In the overall population, 1-OHPHe is significantly associated with low birth weight (LBW) (OR: 2.21, 95% CI: 1.25, 4.03), 2-OHDBF and 2-OHPHe were significantly associated with preterm birth (PTB), respectively (1.43, 95% CI: 1.04, 1.98; 1.38, 95% CI: 1.02, 1.90). GAD-7 score in the third tertile was positively linked to macrosomia (OR: 3.27, 95% CI: 1.28, 10.06). BKMR demonstrated that among pre-pregnancy overweight/obese women (BMI ≧ 24.0), combined exposure to PAHs, depression, and anxiety was positively associated with LBW. Meanwhile, among the women with normal pre-pregnancy BMI (18.5–23.9), combined exposure was positively associated with macrosomia and PTB.</p> SIGNIFICANCE <p>Study results indicate that combined exposure to PAHs, anxiety, and depression increases the risk of adverse birth outcomes in pregnant women.</p> Impact <p><UnorderedList Mark="Bullet"> <ItemContent> <p>This study provides novel evidence that prenatal coexposure to PAHs and psychological distress differentially impacts birth outcomes based on maternal BMI. Our findings underscore the importance of considering both chemical and non-chemical stressors in prenatal care, particularly for at-risk subpopulations. These results inform targeted interventions to improve birth outcomes.</p> </ItemContent> </UnorderedList></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Joint impact of prenatal polycyclic aromatic hydrocarbons, anxiety and depression exposure on birth outcomes across pre-pregnancy BMI categories

  • 期刊论文

  • 发表日期：

    2025年12月13日

查看全文
  • Yunfei Jia,
  • Hualong Zhen,
  • Shuilan Liu,
  • Beibei Zhu,
  • Fengying Hu,
  • Hengshun Cheng,
  • Wei Jv,
  • Yiran Li,
  • Mengjuan Lu,
  • Haiyan Li,
  • Yue Gu,
  • Fangbiao Tao,
  • Minmin Jiang

摘要

Background

While polycyclic aromatic hydrocarbons (PAHs) and maternal psychological distress (anxiety/depression) are risk factors for adverse birth outcomes, their joint effects remain poorly understood, particularly across different pre-pregnancy BMI categories.

Objective

To examine the individual and combined effects of prenatal PAHs exposure and maternal psychological distress on birth outcomes, with emphasis on effect modification by pre-pregnancy BMI.

Methods

In this prospective cohort study, we enrolled 699 pregnant women from two primary hospitals in Hefei, China, from April 2020 through October 2022. Urinary PAHs were assessed using gas chromatography tandem triple quadrupole mass spectrometry (GC-MS/MS). Anxiety and depression symptoms were assessed via Generalized Anxiety Disorder Scale (GAD-7) and Edinburgh Postnatal Depression Scale (EPDS), respectively. Logistic regression and BKMR models were used to explore the individual and combined effects of prenatal PAHs exposure and psychological distress on birth outcomes.

Results

Logistic regression revealed significant associations between PAHs and anxiety symptoms with adverse birth outcomes. In the overall population, 1-OHPHe is significantly associated with low birth weight (LBW) (OR: 2.21, 95% CI: 1.25, 4.03), 2-OHDBF and 2-OHPHe were significantly associated with preterm birth (PTB), respectively (1.43, 95% CI: 1.04, 1.98; 1.38, 95% CI: 1.02, 1.90). GAD-7 score in the third tertile was positively linked to macrosomia (OR: 3.27, 95% CI: 1.28, 10.06). BKMR demonstrated that among pre-pregnancy overweight/obese women (BMI ≧ 24.0), combined exposure to PAHs, depression, and anxiety was positively associated with LBW. Meanwhile, among the women with normal pre-pregnancy BMI (18.5–23.9), combined exposure was positively associated with macrosomia and PTB.

SIGNIFICANCE

Study results indicate that combined exposure to PAHs, anxiety, and depression increases the risk of adverse birth outcomes in pregnant women.

Impact

This study provides novel evidence that prenatal coexposure to PAHs and psychological distress differentially impacts birth outcomes based on maternal BMI. Our findings underscore the importance of considering both chemical and non-chemical stressors in prenatal care, particularly for at-risk subpopulations. These results inform targeted interventions to improve birth outcomes.