The relationship between leptin-to-adiponectin ratio and HOMA-IR and metabolic syndrome in five African-origin populations

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2024年10月17日

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Nadia Sweis,
Julianne Jorgensen,
Julia Zeng,
Candice Choo-Kang,
Joseph Zapater,
Kweku Bedu-Addo,
Terrence Forrester,
Pascal Bovet,
Estelle V. Lambert,
Walter Riesen,
Wolfgang Korte,
Yang Dai,
Lara R. Dugas,
Brian T. Layden,
Amy Luke

摘要

Objective

This cross-sectional study aims to assess the associations between serum leptin, adiponectin, leptin-to-adiponectin ratio (L/A ratio), and metabolic syndrome (MS) and HOMA-IR in five African-origin populations: Ghana, South Africa, Jamaica, Seychelles, and US.

Methods

Clinical measures included serum glucose, insulin, adipokines, blood pressure and anthropometric measures. MS was determined using the Harmonized criteria. The final sample included 2087 adults.

Results

After adjusting for age, sex, and fat mass, L/A ratio, unlike HOMA-IR, was significantly associated with MS across all sites (p < 0.001). Within sites, L/A ratio was only associated with MS and HOMA-IR in the US (p < 0.001) and South Africa (p < 0.01), respectively. Leptin was associated with MS in South Africa only (p < 0.05) but was significantly associated with HOMA-IR across all five sites and within the US (p < 0.05). Similarly, adiponectin was associated with HOMA-IR in South Africa (p < 0.05) and with MS across all five sites (p < 0.001) and within each site separately, except Ghana.

Conclusions

Our study suggests that individuals of the African diaspora in different geographical locations may differ in the determinants of MS. Future studies should investigate the determinants for the disparate relationships between MS, IS and adipokines across different African-origin populations.