Scholarlink

<p>Here we aimed to evaluate the feasibility of distinguishing colorectal microenvironments that support cancer cell growth from those that do not. We hypothesized that patients whose non-tumor-bearing tissue (NBT) obtained from the furthest margins of resected cancer specimens resembled the tumor had a poorer prognosis. Patients with colorectal cancer were divided into groups with tumor-supportive (TSM) or healthy microenvironments using bulk RNA sequencing data from 273 paired NBT and tumor samples. Patients in the TSM group exhibited significantly poorer 5-year recurrence-free survival and overall survival compared with those in the healthy microenvironment group. Pathway and 16S rRNA sequencing analyses revealed that NBT and tumors from the TSM group shared a microbiome composition, along with decreased pathway activity related to microvilli maintenance and flavonoid or vitamin metabolic processes. Single-cell RNA sequencing uncovered upregulated interactions between <i>IL1B</i><sup>high</sup> neutrophils and <i>OLFM4</i><sup>+</sup> epithelial cells in NBTs from the TSM group, as well as organized microniches in TSM tumors, featuring interactions between <i>EMP1</i><sup>high</sup> epithelial cells, <i>IL1B</i><sup>high</sup> neutrophils and <i>GZMK</i><sup>high</sup> CD8<sup>+</sup> T cells. Collectively, the colorectal microenvironment can serve as a prognostic biomarker to effectively predict cancer invasiveness and tumor-promoting inflammation. Maintaining a healthy colorectal mucosal microenvironment, potentially through dietary intervention, is crucial.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Colorectal microenvironment determines the prognosis of colorectal cancer

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年1月7日

查看全文
  • Yeong Hak Bang,
  • Ji Hye Choi,
  • Kyunghee Park,
  • Boram Lee,
  • Kyung Yeon Han,
  • Dae Hee Pyo,
  • Yong Beom Cho,
  • Tae-You Kim,
  • Kyu Joo Park,
  • Seung-Bum Ryoo,
  • Sung-Bum Kang,
  • Chang Sik Yu,
  • Jaeim Lee,
  • Kil-yong Lee,
  • Kyu-Tae Kim,
  • Jin-Young Lee,
  • Hoang Bao Khanh Chu,
  • Nameeta Shah,
  • Shashank Gupta,
  • Pranali Sonpatki,
  • Young-Joon Kim,
  • Woong-Yang Park

摘要

Here we aimed to evaluate the feasibility of distinguishing colorectal microenvironments that support cancer cell growth from those that do not. We hypothesized that patients whose non-tumor-bearing tissue (NBT) obtained from the furthest margins of resected cancer specimens resembled the tumor had a poorer prognosis. Patients with colorectal cancer were divided into groups with tumor-supportive (TSM) or healthy microenvironments using bulk RNA sequencing data from 273 paired NBT and tumor samples. Patients in the TSM group exhibited significantly poorer 5-year recurrence-free survival and overall survival compared with those in the healthy microenvironment group. Pathway and 16S rRNA sequencing analyses revealed that NBT and tumors from the TSM group shared a microbiome composition, along with decreased pathway activity related to microvilli maintenance and flavonoid or vitamin metabolic processes. Single-cell RNA sequencing uncovered upregulated interactions between IL1Bhigh neutrophils and OLFM4+ epithelial cells in NBTs from the TSM group, as well as organized microniches in TSM tumors, featuring interactions between EMP1high epithelial cells, IL1Bhigh neutrophils and GZMKhigh CD8+ T cells. Collectively, the colorectal microenvironment can serve as a prognostic biomarker to effectively predict cancer invasiveness and tumor-promoting inflammation. Maintaining a healthy colorectal mucosal microenvironment, potentially through dietary intervention, is crucial.