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<p>Glycyrrhizin, GL (Glycyrrhizinic acid or Glycyrrhizic acid) is a triterpenoid saponin glycoside found in many species of <i>Glycyrrhiza.</i> On hydrolysis, it forms 18β-glycyrrhetinic acid, GT (glycyrrhetic acid or enoxolone). GL exhibited various pharmacological activities and also serves as a precursor or synthesis of carbenoxolone. This review focuses on various biotechnological approaches used to enhance the GL or GT in response to increasing global needs. So far, attempts have been made to increase GL biosynthesis mainly through elicitation induced by various biotic or abiotic elicitors. In adverse conditions, almost in all cases of elicitation, more or less activation of secondary metabolism and thereby GL content was noted. Few researchers have also tried to induce the biosynthesis in <i>Saccharomyces cerevisiae</i> by introducing the genes whose expression is necessary for the synthesis of enzymes involved in the biosynthetic pathway of GL or GT. This genetic engineering approach showed a vast increase in GL or GT content.</p>

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An overview of strategies used for increasing Glycyrrhizin biosynthesis

  • 期刊论文

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  • 发表日期：

    2026年5月28日

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  • Shriniwas P. Patil,
  • Rajesh R. Patil,
  • Sagar D. Kore,
  • Mayuresh K. Raut

摘要

Glycyrrhizin, GL (Glycyrrhizinic acid or Glycyrrhizic acid) is a triterpenoid saponin glycoside found in many species of Glycyrrhiza. On hydrolysis, it forms 18β-glycyrrhetinic acid, GT (glycyrrhetic acid or enoxolone). GL exhibited various pharmacological activities and also serves as a precursor or synthesis of carbenoxolone. This review focuses on various biotechnological approaches used to enhance the GL or GT in response to increasing global needs. So far, attempts have been made to increase GL biosynthesis mainly through elicitation induced by various biotic or abiotic elicitors. In adverse conditions, almost in all cases of elicitation, more or less activation of secondary metabolism and thereby GL content was noted. Few researchers have also tried to induce the biosynthesis in Saccharomyces cerevisiae by introducing the genes whose expression is necessary for the synthesis of enzymes involved in the biosynthetic pathway of GL or GT. This genetic engineering approach showed a vast increase in GL or GT content.