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<p>Burn wound healing poses a significant medical challenge and remains a critical global health concern, necessitating innovative approaches to improve treatment outcomes. The rising prevalence of burn injuries underscores the pressing need for advanced wound dressings that provide antimicrobial protection, maintain a moist healing environment, and effectively manage exudate. Hydrogels are particularly notable for their biocompatibility, sustainability, and multifunctionality and have emerged as promising materials to meet these requirements. This study focuses on the development of novel multifunctional hydrogels using acetic acid (AA) and gelatin as base materials, supplemented with functional additives such as chitosan (CS), selenium (SE), silver (Ag) nanopowders or copper (Cu) nanopowders, and natural bioactive compounds including almond oil, neem oil, propolis, and vitamins A and C. The study involves the preparation of hydrogels, comprehensive characterization, and functional performance evaluation. Hydrogels were characterized by Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and X-ray diffraction (XRD) to assess chemical structure, thermal stability, and crystalline features. Functional performance was evaluated by moisture content, swelling behavior at 37℃, and drug release kinetics, while biocompatibility was assessed using the methyl thiazolyl tetrazolium (MTT) assay to determine cytotoxicity and cell viability at varying concentrations. All hydrogels maintained high moisture content (~ 90%) and exhibited large, stable swelling at 37℃ (~ 870–1005%). The results demonstrated that SE-AA-based hydrogels exhibited the highest cell viability (up to ~ 160% of control) with no evidence of cytotoxicity, effectively supporting tissue regeneration, cellular attachment, and growth. Metal-containing variants (Ag-gelatin and Cu-gelatin) maintained acceptable viability (~ 80% and ~ 70%, respectively) while providing infection-oriented functionality. FTIR/TGA/XRD collectively supported cohesive network formation and thermal robustness. Overall, SE-AA-based hydrogels (particularly 0.6 and 1.0&#xa0;g SE) emerged as lead candidates by combining biocompatibility, moisture management, and controlled swelling, while Ag/Cu-gelatin hydrogels appear suited to infection-prone contexts. These findings support the potential of multifunctional hydrogels as advanced dressings for burn wound care.</p>

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Design and development of advanced biocompatible hydrogels for burn wound healing applications

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年12月10日

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  • Manju Paramshetty,
  • Zainab Khan,
  • Shashank Lokesh,
  • Chaitanya Parmar,
  • Balakrishnan Subeshan,
  • Shang-You Yang,
  • Eylem Asmatulu

摘要

Burn wound healing poses a significant medical challenge and remains a critical global health concern, necessitating innovative approaches to improve treatment outcomes. The rising prevalence of burn injuries underscores the pressing need for advanced wound dressings that provide antimicrobial protection, maintain a moist healing environment, and effectively manage exudate. Hydrogels are particularly notable for their biocompatibility, sustainability, and multifunctionality and have emerged as promising materials to meet these requirements. This study focuses on the development of novel multifunctional hydrogels using acetic acid (AA) and gelatin as base materials, supplemented with functional additives such as chitosan (CS), selenium (SE), silver (Ag) nanopowders or copper (Cu) nanopowders, and natural bioactive compounds including almond oil, neem oil, propolis, and vitamins A and C. The study involves the preparation of hydrogels, comprehensive characterization, and functional performance evaluation. Hydrogels were characterized by Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), and X-ray diffraction (XRD) to assess chemical structure, thermal stability, and crystalline features. Functional performance was evaluated by moisture content, swelling behavior at 37℃, and drug release kinetics, while biocompatibility was assessed using the methyl thiazolyl tetrazolium (MTT) assay to determine cytotoxicity and cell viability at varying concentrations. All hydrogels maintained high moisture content (~ 90%) and exhibited large, stable swelling at 37℃ (~ 870–1005%). The results demonstrated that SE-AA-based hydrogels exhibited the highest cell viability (up to ~ 160% of control) with no evidence of cytotoxicity, effectively supporting tissue regeneration, cellular attachment, and growth. Metal-containing variants (Ag-gelatin and Cu-gelatin) maintained acceptable viability (~ 80% and ~ 70%, respectively) while providing infection-oriented functionality. FTIR/TGA/XRD collectively supported cohesive network formation and thermal robustness. Overall, SE-AA-based hydrogels (particularly 0.6 and 1.0 g SE) emerged as lead candidates by combining biocompatibility, moisture management, and controlled swelling, while Ag/Cu-gelatin hydrogels appear suited to infection-prone contexts. These findings support the potential of multifunctional hydrogels as advanced dressings for burn wound care.