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<p><i>Vitex quinata</i> (<i>Lamiaceae</i>), distributed widely in temperate and tropical Asian countries, is an underexplored species. This study identified the chemical composition of <i>V. quinata</i> leaf essential oil (VQLEO) and evaluated its antioxidant, anti-tyrosinase, antibacterial, and biofilm inhibition activity. GC–MS analysis of VQLEO revealed 36 phytoconstituents with longifolene (52.87%), spathulenol (9.54%), and ar-curcumene (5.74%) as the predominant constituents. VQLEO showed weak antioxidant activity in both DPPH and ABTS assays (IC<sub>50</sub>: 18.83 ± 0.52&#xa0;and 18.53 ± 0.18&#xa0;mg/mL). It also exhibited an inhibitory effect against mushroom tyrosinase enzyme (IC<sub>50</sub>: 13.85 ± 0.81&#xa0;mg/mL). VQLEO displayed significant antibacterial activity against <i>Escherichia coli, Staphylococcus aureus, Streptococcus mutans,</i> and <i>Klebsiella pneumoniae</i> with MIC values ranging from 12.5&#xa0;to 25&#xa0;μg/mL Furthermore, the VQLEO effectively inhibited biofilm formation at its respective sub-MIC concentration, with the highest percentage inhibition being observed against <i>E. coli</i> (79.41%), followed by <i>S. aureus</i> (78.72%), <i>S. mutans</i> (71.40%), and <i>K. pneumoniae</i> (65.58%).</p>

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GC–MS characterization and biological activities of Vitex quinata leaf essential oil: Antioxidant, tyrosinase inhibitory and antibiofilm potential

  • 期刊论文

  • 发表日期：

    2026年7月8日

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  • Alaka Mohanty,
  • Prabhat Kumar Das,
  • Ambika Sahoo,
  • Sanghamitra Nayak,
  • Pratap Chandra Panda,
  • Sujata Mohanty

摘要

Vitex quinata (Lamiaceae), distributed widely in temperate and tropical Asian countries, is an underexplored species. This study identified the chemical composition of V. quinata leaf essential oil (VQLEO) and evaluated its antioxidant, anti-tyrosinase, antibacterial, and biofilm inhibition activity. GC–MS analysis of VQLEO revealed 36 phytoconstituents with longifolene (52.87%), spathulenol (9.54%), and ar-curcumene (5.74%) as the predominant constituents. VQLEO showed weak antioxidant activity in both DPPH and ABTS assays (IC50: 18.83 ± 0.52 and 18.53 ± 0.18 mg/mL). It also exhibited an inhibitory effect against mushroom tyrosinase enzyme (IC50: 13.85 ± 0.81 mg/mL). VQLEO displayed significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Streptococcus mutans, and Klebsiella pneumoniae with MIC values ranging from 12.5 to 25 μg/mL Furthermore, the VQLEO effectively inhibited biofilm formation at its respective sub-MIC concentration, with the highest percentage inhibition being observed against E. coli (79.41%), followed by S. aureus (78.72%), S. mutans (71.40%), and K. pneumoniae (65.58%).