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<p><i>Globba annamensis</i> (Zingiberaceae) is a little-studied herbaceous species. This study reports the first investigation of the leaf essential oil of <i>G. annamensis</i> collected in Vietnam, focusing on its chemical composition, antimicrobial activity, and mosquito larvicidal potential. The chemical composition was analyzed by gas chromatography–mass spectrometry (GC–MS) for compound identification and gas chromatography with flame ionization detection (GC–FID) for quantitative determination. A total of 33 constituents were identified, accounting for 97.79% of the total oil, with β-pinene (49.78%) as the major component, followed by β-caryophyllene (12.77%), α-pinene (5.95%), and safrole (4.56%). The essential oil exhibited notable antimicrobial activity against <i>Enterococcus faecalis</i>, <i>Staphylococcus aureus</i>, <i>Bacillus cereus</i>, <i>Salmonella enterica</i>, and <i>Candida albicans</i>, with minimum inhibitory concentration (MIC) values ranging from 16 to 128 µg/mL. The reference drugs streptomycin for bacteria and cycloheximide for yeast showed MIC values of 32 to 256 µg/mL and 64 µg/mL, respectively. Larvicidal assays demonstrated strong activity against <i>Aedes aegypti</i> and <i>Culex quinquefasciatus</i>, with LC<sub>50</sub> values ranging from 26.56 to 34.35 µg/mL and LC<sub>90</sub> values from 35.21 to 41.11 µg/mL after 24 h and 48 h of exposure. In contrast, the positive control permethrin exhibited higher potency, with LC<sub>50</sub> values of 0.00464 to 0.01500 µg/mL under the same conditions. These findings indicate that the leaf essential oil of <i>G. annamensis</i> is a promising natural source of bioactive compounds for antimicrobial and vector-control applications.</p>

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Exploring the chemical composition and antimicrobial and mosquito larvicidal activities of the essential oil from Globba annamensis

  • 期刊论文

  • 发表日期：

    2026年6月17日

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  • Do N. Dai,
  • Vo T. Dung,
  • Le T. Huong,
  • Nguyen H. Hung,
  • Bui B. Thinh

摘要

Globba annamensis (Zingiberaceae) is a little-studied herbaceous species. This study reports the first investigation of the leaf essential oil of G. annamensis collected in Vietnam, focusing on its chemical composition, antimicrobial activity, and mosquito larvicidal potential. The chemical composition was analyzed by gas chromatography–mass spectrometry (GC–MS) for compound identification and gas chromatography with flame ionization detection (GC–FID) for quantitative determination. A total of 33 constituents were identified, accounting for 97.79% of the total oil, with β-pinene (49.78%) as the major component, followed by β-caryophyllene (12.77%), α-pinene (5.95%), and safrole (4.56%). The essential oil exhibited notable antimicrobial activity against Enterococcus faecalis, Staphylococcus aureus, Bacillus cereus, Salmonella enterica, and Candida albicans, with minimum inhibitory concentration (MIC) values ranging from 16 to 128 µg/mL. The reference drugs streptomycin for bacteria and cycloheximide for yeast showed MIC values of 32 to 256 µg/mL and 64 µg/mL, respectively. Larvicidal assays demonstrated strong activity against Aedes aegypti and Culex quinquefasciatus, with LC50 values ranging from 26.56 to 34.35 µg/mL and LC90 values from 35.21 to 41.11 µg/mL after 24 h and 48 h of exposure. In contrast, the positive control permethrin exhibited higher potency, with LC50 values of 0.00464 to 0.01500 µg/mL under the same conditions. These findings indicate that the leaf essential oil of G. annamensis is a promising natural source of bioactive compounds for antimicrobial and vector-control applications.