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<p>Many wild plants, despite their growing recognition as a sustainable source of nutritional and therapeutic agents, are still undiscovered in Azad Jammu and Kashmir, Pakistan. This study provides the first integrated evaluation of the nutritional, antioxidant, antibacterial, anticancer, and phytochemical profile of <i>Persicaria amplexicaulis</i>, a locally used plant in District Poonch, Azad Kashmir, Pakistan. Nutritional analysis (proximate and mineral analyses) showed significant levels of carbohydrates, fibers, fats, and minerals. Antioxidant activity, assessed using multiple radical-scavenging and reducing assays, showed a dose-dependent effect. The methanol extract showed the lowest IC<sub>50</sub> value (36.2 ± 2.1 µg/mL) against hydroxyl radicals, indicating greater antioxidant ability. Phytochemical analysis revealed a significant level of flavonoids, phenolics, ascorbic acid, and carotenoids. GC–MS identified 31 compounds, mainly oleic acid, 9-octadecenoic acid (E), and 6-octadecenoic acid. The plant leaf extract showed noteworthy antibacterial activity against the tested bacteria, with a higher zone of inhibition against <i>Pseudomonas aeruginosa</i> (18.64 ± 0.02 mm). Furthermore, the anticancer activity of <i>P. amplexicaulis</i> was also assessed against PC3 and HeLa cells. Notably, the methanol extract exhibited profound cytotoxicity against PC3 prostate cancer cells (IC<sub>50</sub> = 9.70 ± 0.75 µg/mL) and comparatively weaker activity against HeLa cells (IC<sub>50</sub> = 11.47 ± 2.49 µg/mL), demonstrating selective anticancer activity. Current findings revealed the nutraceutical and ethnopharmacological potential of <i>P. amplexicaulis</i> L. along with its nutritional value.</p>

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Nutritional profile, phytochemicals, and bioactivities of the Himalayan herbal tea plant Persicaria amplexicaulis

  • 期刊论文

  • 发表日期：

    2026年5月2日

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  • Amna Mustafa,
  • Ansar Mehmood,
  • Imtiaz Hussain,
  • Muhammad Imran Hamza,
  • Khawaja Shafique Ahmad,
  • Mushtaq Ahmad

摘要

Many wild plants, despite their growing recognition as a sustainable source of nutritional and therapeutic agents, are still undiscovered in Azad Jammu and Kashmir, Pakistan. This study provides the first integrated evaluation of the nutritional, antioxidant, antibacterial, anticancer, and phytochemical profile of Persicaria amplexicaulis, a locally used plant in District Poonch, Azad Kashmir, Pakistan. Nutritional analysis (proximate and mineral analyses) showed significant levels of carbohydrates, fibers, fats, and minerals. Antioxidant activity, assessed using multiple radical-scavenging and reducing assays, showed a dose-dependent effect. The methanol extract showed the lowest IC50 value (36.2 ± 2.1 µg/mL) against hydroxyl radicals, indicating greater antioxidant ability. Phytochemical analysis revealed a significant level of flavonoids, phenolics, ascorbic acid, and carotenoids. GC–MS identified 31 compounds, mainly oleic acid, 9-octadecenoic acid (E), and 6-octadecenoic acid. The plant leaf extract showed noteworthy antibacterial activity against the tested bacteria, with a higher zone of inhibition against Pseudomonas aeruginosa (18.64 ± 0.02 mm). Furthermore, the anticancer activity of P. amplexicaulis was also assessed against PC3 and HeLa cells. Notably, the methanol extract exhibited profound cytotoxicity against PC3 prostate cancer cells (IC50 = 9.70 ± 0.75 µg/mL) and comparatively weaker activity against HeLa cells (IC50 = 11.47 ± 2.49 µg/mL), demonstrating selective anticancer activity. Current findings revealed the nutraceutical and ethnopharmacological potential of P. amplexicaulis L. along with its nutritional value.