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<p>Silver nanoparticles (AgNPs) were synthesized using <i>Cyamopsis tetragonoloba</i> (<i>C. tetragonoloba</i>) pods (CTP-NPs) powder extract. The&#xa0;following techniques&#xa0;UV–visible spectroscopy, fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used for the characterization of these synthesized nanoparticles. UV–Visible Spectroscopy confirmed the formation of AgNPs via a distinct Surface Plasmon Resonance (SPR) peak observed at 412&#xa0;nm, indicating successful reduction. FT-IR Analysis identified key functional groups (e.g., N–H, C = O stretching) responsible for capping and stabilization, with major shifts observed at 3411&#xa0;cm<sup>−1</sup> and 1735.73&#xa0;cm<sup>−1</sup>. X-Ray Diffraction (XRD): Revealed a face-centered cubic (FCC) crystalline structure. Scanning Electron Microscopy (SEM): Illustrated a predominantly spherical morphology with average particle size 13&#xa0;nm. The CTP-AgNPs IC<sub>50</sub> values revealed notable variations in DPPH (183.61&#xa0;μg/mL) in comparison to the ascorbic acid standard (25.7&#xa0;μg/mL) and hydroxyl radical activity (53.6&#xa0;μg/mL) in comparison to ascorbic acid (22.47&#xa0;μg/mL). Antibacterial property of CTP-AgNPs against&#xa0;<i>Escherichia coli</i> (<i>E. coli</i>)&#xa0;and <i>Bacillus subtilis</i> (<i>B. subtilis</i>) was proved by zone of inhibition 11 ± 0.79&#xa0;mm and 12 ± 0.78&#xa0;mm per 100&#xa0;μg/mL respectively.&#xa0;In vitro anticancer assay demonstrated IC<sub>50</sub> value of 18.25&#xa0;μg/mL against A549 lung cancer cell line, which confirms its potent anticancer potential. Overall, the&#xa0;CTP mediated bio-synthesized AgNPs proved promising in vitro antioxidants by free radical scavenging, antimicrobial by zone of inhibition and anticancer by cytotoxic properties.</p>

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Cyamopsis tetragonoloba pod extract: A green route to multifunctional silver nanoparticles with enhanced biomedical activity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月2日

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  • Braivy Anto,
  • Suriyavathana Muthukrishnan,
  • Anandhi E.,
  • Thamaraiselvi Ganesan,
  • Indumathi K.P.,
  • Rasiravathanahalli Kaveriyappan Govindarajan,
  • Sivakumar Murugesan,
  • Sivakumar Loganathan,
  • Marcello Iriti

摘要

Silver nanoparticles (AgNPs) were synthesized using Cyamopsis tetragonoloba (C. tetragonoloba) pods (CTP-NPs) powder extract. The following techniques UV–visible spectroscopy, fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used for the characterization of these synthesized nanoparticles. UV–Visible Spectroscopy confirmed the formation of AgNPs via a distinct Surface Plasmon Resonance (SPR) peak observed at 412 nm, indicating successful reduction. FT-IR Analysis identified key functional groups (e.g., N–H, C = O stretching) responsible for capping and stabilization, with major shifts observed at 3411 cm−1 and 1735.73 cm−1. X-Ray Diffraction (XRD): Revealed a face-centered cubic (FCC) crystalline structure. Scanning Electron Microscopy (SEM): Illustrated a predominantly spherical morphology with average particle size 13 nm. The CTP-AgNPs IC50 values revealed notable variations in DPPH (183.61 μg/mL) in comparison to the ascorbic acid standard (25.7 μg/mL) and hydroxyl radical activity (53.6 μg/mL) in comparison to ascorbic acid (22.47 μg/mL). Antibacterial property of CTP-AgNPs against Escherichia coli (E. coli) and Bacillus subtilis (B. subtilis) was proved by zone of inhibition 11 ± 0.79 mm and 12 ± 0.78 mm per 100 μg/mL respectively. In vitro anticancer assay demonstrated IC50 value of 18.25 μg/mL against A549 lung cancer cell line, which confirms its potent anticancer potential. Overall, the CTP mediated bio-synthesized AgNPs proved promising in vitro antioxidants by free radical scavenging, antimicrobial by zone of inhibition and anticancer by cytotoxic properties.