Geographic and botanical determinants of propolis: variability in chemical constituents and antimicrobial effects
摘要
Propolis, a natural resinous material derived from plant exudates and generated by bees, has been extensively studied for its various pharmacological properties. The purpose of this review is to have a comprehensive overview of the influences of geography (latitudes, altitudes, and climate/season), and botany (dominant resin-producing plant sources/local vegetation) in its impact on the chemical profile of propolis and its antimicrobial activity. It uncovers the complicated relationship between environmental factors and the bioactivity of propolis, highlighting those distinct regional varieties, such as Brazilian red propolis, Mediterranean propolis, and Asian varieties, possess unique chemical fingerprints that contribute to their varying degrees of antimicrobial activity. It includes many areas that revealed the main ingredients of propolis (flavonoids, phenolic acids, and terpenoids) shown substantial variation by geographical latitude, altitude, and local vegetation. Temperate zone propolis is abundant in flavonoids such as pinocembrin and galangin. In contrast, tropical propolis has elevated concentrations of diterpenes and prenylated substances, often linked to more potent antibacterial properties. The antimicrobial efficacy of propolis is attributed to its chemical ingredients, which can combat a wide range of pathogens such as bacteria, fungi, and viruses.Moreover, this review discusses the limitations of standardizing propolis as a therapeutic agent owing to its compositional variability while signifying approaches for improving quality control.
Graphical AbstractGeoclimatic factors, including differences between temperate and tropical zones, influence variations in the chemical composition of honeybee hive products, such as propolis.