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Purpose <p>This study aimed to optimize the supercritical CO₂ (SC-CO<sub>2</sub>) extraction process for <i>Eleutherococcus senticosus</i> extracts (ESE) to maximize yield, and to evaluate the antioxidant activity of the obtained extracts.</p> Methods <p>The extraction was performed using SC-CO<sub>2</sub> under conditions below the boiling point to preserve heat-sensitive compounds. Key factors (temperature, pressure, and time) were investigated, and the optimal process conditions were determined using the response surface methodology. The antioxidant activity of ESE was assessed by measuring its scavenging effect on 2,2-diphenyl-1-picrylhydrazyl free radicals.</p> Results <p>The optimal extraction conditions were identified as a temperature of 60&#xa0;°C, pressure of 30&#xa0;MPa, and an extraction time of 2&#xa0;h, yielding 1.88 ± 0.05% of ESE. Phytol was identified as a primary constituent. The ESE exhibited notable antioxidant activity, and its concentration exhibited a positive correlation with antioxidant activity.</p> Conclusion <p>This study made a significant contribution to the field by enhancing the extraction process of ESE and providing a valuable direction for the study of antioxidant bioactive substances.</p>

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Eleutherococcus senticosus extracts through a supercritical CO2 extraction process for antioxidant application

  • 期刊论文

  • 发表日期：

    2026年3月4日

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  • Zening Wang,
  • Gaolei Xi,
  • Changtong Lu,
  • Yibo Ning,
  • Xueying Cao,
  • Zhifei Chen,
  • Yongzhen Zhao,
  • Shuqing Ao,
  • Tao Jia,
  • Xiuhua Zhao

摘要

Purpose

This study aimed to optimize the supercritical CO₂ (SC-CO2) extraction process for Eleutherococcus senticosus extracts (ESE) to maximize yield, and to evaluate the antioxidant activity of the obtained extracts.

Methods

The extraction was performed using SC-CO2 under conditions below the boiling point to preserve heat-sensitive compounds. Key factors (temperature, pressure, and time) were investigated, and the optimal process conditions were determined using the response surface methodology. The antioxidant activity of ESE was assessed by measuring its scavenging effect on 2,2-diphenyl-1-picrylhydrazyl free radicals.

Results

The optimal extraction conditions were identified as a temperature of 60 °C, pressure of 30 MPa, and an extraction time of 2 h, yielding 1.88 ± 0.05% of ESE. Phytol was identified as a primary constituent. The ESE exhibited notable antioxidant activity, and its concentration exhibited a positive correlation with antioxidant activity.

Conclusion

This study made a significant contribution to the field by enhancing the extraction process of ESE and providing a valuable direction for the study of antioxidant bioactive substances.