Scholarlink

<p>Several <i>Achillea</i> species have been reported to exhibit cytotoxic, wound-healing, antioxidant, and antibacterial activities. In this study, the phytochemical composition of aqueous ethanol extracts from ten <i>Achillea</i> taxa was investigated using LC–MS/MS analysis. The antioxidant potential of the extracts was evaluated, and their inhibitory effects on acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-glucosidase, and α-amylase enzymes were assessed. Quinic acid (11.95–43.93&#xa0;µg/mg), chlorogenic acid (9.82–32.75&#xa0;µg/mg), cynaroside (9.82–32.75&#xa0;µg/mg), and rutin (0.56–21.11&#xa0;µg/mg) were identified as the major compounds. Among the tested species, <i>Achillea teretifolia</i> exhibited the strongest antioxidant activity in ABTS and DPPH assays, with IC<sub>50</sub> values of 231.5 ± 0.72 and 11.31 ± 0.25&#xa0;µg/mL, respectively. In contrast, <i>Achillea lycaonica</i> showed the most potent tyrosinase inhibition (IC<sub>50</sub>: 1.83 ± 0.26&#xa0;µg/mL). The extracts also demonstrated inhibitory activity against α-amylase and α-glucosidase, with IC<sub>50</sub> values ranging from 0.39 to 195.8&#xa0;mg/mL and 0.19 to 39.18&#xa0;µg/mL, respectively. Furthermore, molecular docking studies using AutoDock Vina and ChemOffice explored the interactions of quinic acid, the predominant phenolic compound, with tyrosinase, α-amylase, and α-glucosidase.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Phytochemical composition, antioxidant potential, and inhibitory activity on enzymes associated with carbohydrate metabolism and skin whitening with molecular docking of ten Achillea taxa

  • 期刊论文

  • 发表日期：

    2026年1月29日

查看全文
  • Nuraniye Eruygur,
  • Yavuz Bagci,
  • Merve Kocak,
  • Suleyman Dogu,
  • Nagihan Faydali,
  • Mustafa Abdullah Yilmaz,
  • Oguz Cakir

摘要

Several Achillea species have been reported to exhibit cytotoxic, wound-healing, antioxidant, and antibacterial activities. In this study, the phytochemical composition of aqueous ethanol extracts from ten Achillea taxa was investigated using LC–MS/MS analysis. The antioxidant potential of the extracts was evaluated, and their inhibitory effects on acetylcholinesterase, butyrylcholinesterase, tyrosinase, α-glucosidase, and α-amylase enzymes were assessed. Quinic acid (11.95–43.93 µg/mg), chlorogenic acid (9.82–32.75 µg/mg), cynaroside (9.82–32.75 µg/mg), and rutin (0.56–21.11 µg/mg) were identified as the major compounds. Among the tested species, Achillea teretifolia exhibited the strongest antioxidant activity in ABTS and DPPH assays, with IC50 values of 231.5 ± 0.72 and 11.31 ± 0.25 µg/mL, respectively. In contrast, Achillea lycaonica showed the most potent tyrosinase inhibition (IC50: 1.83 ± 0.26 µg/mL). The extracts also demonstrated inhibitory activity against α-amylase and α-glucosidase, with IC50 values ranging from 0.39 to 195.8 mg/mL and 0.19 to 39.18 µg/mL, respectively. Furthermore, molecular docking studies using AutoDock Vina and ChemOffice explored the interactions of quinic acid, the predominant phenolic compound, with tyrosinase, α-amylase, and α-glucosidase.