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<p><i>Hypericum androsaemum</i>, a member of the genus <i>Hypericum</i>, is traditionally utilized for its wound healing properties and as a herbal tea. This study investigates the antimicrobial activities of its extracts against Gram-positive and Gram-negative bacteria as well as yeast. The antimicrobial efficacy of dichloromethane, methanol, and water extracts from the leaves and fruits of H. androsaemum, was assessed via microdilution and time-kill assays. Results indicated notable inhibitory effects against specific Gram-positive bacteria, particularly <i>Staphylococcus aureus</i> and <i>Staphylococcus epidermidis</i>, with minimum inhibitory concentrations (MICs) of 1.22&#xa0;μg/mL and 2.44&#xa0;μg/mL, respectively. Furthermore, biofilm formation assays indicated that selected fruit methanol (<b>FM</b>) and leaves dichloromethane (<b>LD</b>) extracts could hinder bacterial adherence for <i>Staphylococcus</i> strains, thus showing potential as antibiofilm agents. Gas chromatography-mass spectrometry (GC–MS) revealed a diverse fatty acid profile for the two extracts, with key components including linoleic acid (7.84% in <b>LD</b> and 28.916% in <b>FM</b>) and oleic acid (10.953% in <b>LD</b> and 24.270% in <b>FM</b>), which are linked to antimicrobial activity. These findings suggest that <i>H</i>. <i>androsaemum</i> extracts possess significant antimicrobial properties, warranting further research on their potential applications in combating microbial resistance and infections.</p>

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Antimicrobial and antibiofilm potential of Hypericum androsaemum extracts with emphasis on fatty acid composition

  • 期刊论文

  • 发表日期：

    2026年1月29日

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  • Nurdan Yazici,
  • Esra Eroğlu Özkan,
  • Emel Mataracı Kara,
  • Yagmur Yazici,
  • Nese Ular Çağatay,
  • Murat Emrah Maviş

摘要

Hypericum androsaemum, a member of the genus Hypericum, is traditionally utilized for its wound healing properties and as a herbal tea. This study investigates the antimicrobial activities of its extracts against Gram-positive and Gram-negative bacteria as well as yeast. The antimicrobial efficacy of dichloromethane, methanol, and water extracts from the leaves and fruits of H. androsaemum, was assessed via microdilution and time-kill assays. Results indicated notable inhibitory effects against specific Gram-positive bacteria, particularly Staphylococcus aureus and Staphylococcus epidermidis, with minimum inhibitory concentrations (MICs) of 1.22 μg/mL and 2.44 μg/mL, respectively. Furthermore, biofilm formation assays indicated that selected fruit methanol (FM) and leaves dichloromethane (LD) extracts could hinder bacterial adherence for Staphylococcus strains, thus showing potential as antibiofilm agents. Gas chromatography-mass spectrometry (GC–MS) revealed a diverse fatty acid profile for the two extracts, with key components including linoleic acid (7.84% in LD and 28.916% in FM) and oleic acid (10.953% in LD and 24.270% in FM), which are linked to antimicrobial activity. These findings suggest that H. androsaemum extracts possess significant antimicrobial properties, warranting further research on their potential applications in combating microbial resistance and infections.