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<p>Innate immunity, such as MR1-dependent MAIT cell response, is essential for host defense against bacteria. Yet the key cells mediating MR1 antigen presentation were unclear. Recently, McWilliam and colleagues identified macrophages as the dominant MR1-expressing cells responsible for presenting microbial antigens to activate antibacterial MAIT cells and regulate microbiota composition.</p>

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Macrophages mediate MR1-antigen presentation for antibacterial MAIT immunity

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月20日

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  • Jiahui Qiao,
  • Yang Liu

摘要

Innate immunity, such as MR1-dependent MAIT cell response, is essential for host defense against bacteria. Yet the key cells mediating MR1 antigen presentation were unclear. Recently, McWilliam and colleagues identified macrophages as the dominant MR1-expressing cells responsible for presenting microbial antigens to activate antibacterial MAIT cells and regulate microbiota composition.