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<p>Adaptive immunity relies on antibodies and memory B and T cells, with memory T cells providing "reactive memory". These cells either circulate in the blood or remain as tissue-resident memory T cells, yet the epigenetic mechanisms underlying their recall function and maintenance are not well understood. Here, we present a comprehensive analysis of 56 reduced representation bisulfite sequencing (RRBS) datasets from 22 memory CD4 and CD8 T-cell populations isolated from human bone marrow, intestine, spleen, lung, skin, and peripheral blood, including surface CD69-positive and CD69-negative cells. Our study reveals unique DNA hypomethylation patterns in tissue-resident memory T cells, particularly in regions associated with genes involved in tissue homing, residency, and transcription factors regulating recall effector memory. The methylomes and differential methylation signatures identified here serve as a valuable resource for understanding the epigenetic program&#xa0;of memory T lymphocytes, their roles in immunological recall, and their maintenance within specific tissues.</p> Graphical Abstract <p></p>

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Methylomes of human CD4 and CD8 memory T lymphocytes reveal tissue-specific epigenetic signatures for maintenance and recall function

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月1日

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  • Xiangyi Deng,
  • Weijie Du,
  • Gilles Gasparoni,
  • Abdulrahman Salhab,
  • Karl Nordström,
  • Jinchan Li,
  • Viktoria Wagner,
  • Erping Zhang,
  • Joachim Wachtlin,
  • Juliane Bodo,
  • Simon Reinke,
  • Hong Lei,
  • Carsten Perka,
  • Sebastian Hardt,
  • Thomas Dörner,
  • Christoph Holmer,
  • Mario Tönnies,
  • Torsten Bauer,
  • Hyun-Dong Chang,
  • Julia K. Polansky,
  • Jörn Walter,
  • Pawel Durek,
  • Andreas Radbruch,
  • Jun Dong

摘要

Adaptive immunity relies on antibodies and memory B and T cells, with memory T cells providing "reactive memory". These cells either circulate in the blood or remain as tissue-resident memory T cells, yet the epigenetic mechanisms underlying their recall function and maintenance are not well understood. Here, we present a comprehensive analysis of 56 reduced representation bisulfite sequencing (RRBS) datasets from 22 memory CD4 and CD8 T-cell populations isolated from human bone marrow, intestine, spleen, lung, skin, and peripheral blood, including surface CD69-positive and CD69-negative cells. Our study reveals unique DNA hypomethylation patterns in tissue-resident memory T cells, particularly in regions associated with genes involved in tissue homing, residency, and transcription factors regulating recall effector memory. The methylomes and differential methylation signatures identified here serve as a valuable resource for understanding the epigenetic program of memory T lymphocytes, their roles in immunological recall, and their maintenance within specific tissues.

Graphical Abstract