<p>In the last decade, scientists have shown significant interest in natural materials because of their functional benefits. Green technology through the extraction of natural products has long been valued due to the awareness of the environmental standards for global health. Natural fibers are particularly vulnerable to microbial assault, which causes staining and bad odor along with deterioration of strength and other mechanical properties; they also provide the lowest level of ultraviolet (UV) protection. This study presents a comparative investigation of the functionalization of different cellulosic fabrics (viscose and cotton) using extracts from moringa, green tea, and pomegranate in combination with chitosan to provide these fabrics with antimicrobial and UV-protective properties for the development of medical wearables and healthcare textile applications such as bed sheets, surgical caps, and surgical gowns. The physical, mechanical, and chemical properties were determined for all samples. From two-way analysis of variance (ANOVA), it was observed that all variables, with the exception of weft elongation between textile materials and treated materials, and weft-breaking load for treated samples, achieved significant differences between textile materials and treated samples. In addition, one-way ANOVA indicated significant effects for all variables according to radar chart area analysis. The surface morphology for untreated and treated samples was measured using scanning electron microscopy and energy-dispersive X-ray spectroscopy. The antibacterial activity, UV protection, and color strength of the treated cellulosic fabrics were enhanced by adding herbal natural extracts and chitosan as natural modifiers. Moreover, the dye uptake and color strength (dark shade) of reactive black 5 (RB5) dye increased without the need for additional dye and less discharge of dye into the environment.</p>