<p>In the past decades the ability to create durable, and sustainable concrete has largely been achievable thanks to the relative abundance, and regional availability of supplementary cementing materials (SCMs). SCMs are widely recognized to reduce and even mitigate concrete damage due to alkali silica reaction (ASR). In the upcoming decade, increasing scarcity of traditional SCMs is anticipated, and therefore there is a need to explore alternative concrete technologies and their implications on durability. The scope and objectives of this study are to: (i) develop and justify a multi-modal exposure scheme of carbonation curing followed by ASR for mortar and concrete, (ii) examine the influence of carbonation curing on the mechanical, transport and microstructure of concrete made with reactive aggregates (Sudbury, Spratt and Jobe), and (iii) examine the mechanistic and symptomatic implications of sequential accelerated laboratory carbonation curing and ASR exposure conditions on material properties and performance. Key outcomes of this study are: (i) compared to mortar tests, testing concrete prisms is more conservative regarding evaluation of the potential for accelerated carbonation curing to reduce/mitigate/suppress ASR-induced expansion, (ii) the addition of Ca(OH)₂ to the NaOH (ASTM C1260 exposure solution), as an external Ca source, did not increase ASR-induced expansions, (iii) compressive strength and carbonation depth did not vary markedly between the atmospheric and accelerated carbonation cured specimens and neither between Sudbury, Spratt and Jobe aggregates, (iv) Jobe prisms subjected to accelerated carbonation curing developed 10 times wider cracks than Jobe prisms subjected to atmospheric curing, and (v) accelerated carbonation curing may be a partial solution to reduce ASR of concrete made with highly reactive and very highly reactive aggregates.</p>