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Background <p>Sea buckthorn (<i>Elaeagnus rhamnoides</i> (L.) A. Nelson) berry extract has been shown to favorably affect bone biomarkers in vitro, indicating its therapeutic potential. However, the effects of <i>Elaeagnus rhamnoides</i> (L.) A. Nelson on the skeletal system in diabetic individuals are unknown.</p> Methods <p>We provide the first evidence on the impact of <i>Elaeagnus rhamnoides</i> (L.) A. Nelson berries administered individually (500 and 1000&#xa0;mg/kg/day for 3 months) and simultaneously with metformin (150&#xa0;mg/kg/day for 3 months) on bone health in Zucker diabetic fatty (ZDF) rats, a suitable animal model of type 2 diabetes mellitus (T2DM). Biochemical and macroscopic analyses, microcomputed tomography, histological examination, and mechanical testing of bone were performed.</p> Results <p>Compared to untreated ZDF rats, ZDF rats co-administered with metformin and a higher dose of <i>Elaeagnus rhamnoides</i> (L.) A. Nelson showed reduced blood glucose and triglyceride levels, enhanced bone turnover markers, and improved several parameters of trabecular bone microarchitecture and matrix quality (<i>p</i> &lt; 0.05). Minor positive effects on biochemical parameters and microstructural metrics of trabecular bone were noted in ZDF rats with concomitant administration of metformin and a lower dose of <i>Elaeagnus rhamnoides</i> (L.) A. Nelson (<i>p</i> &lt; 0.05). ZDF rats given only the lower dose of <i>Elaeagnus rhamnoides</i> (L.) A. Nelson had decreased both glucose levels and the number of immature collagen fibers in trabecular bone (<i>p</i> &lt; 0.05).</p> Conclusion <p>These findings demonstrate that combination therapy with <i>Elaeagnus rhamnoides</i> (L.) A. Nelson and metformin appears to be more effective in alleviating trabecular bone abnormalities associated with T2DM than monotherapy.</p>

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Simultaneous Administration of Sea Buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) and Metformin Modulates Trabecular Bone Microarchitecture in Type 2 Diabetic Rat Model

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月23日

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  • Monika Martiniakova,
  • Veronika Kovacova,
  • Roman Biro,
  • Noemi Penzes,
  • Anna Sarocka,
  • Vladimira Mondockova,
  • Piotr Londzin,
  • Joanna Folwarczna,
  • Veronika Mestanova,
  • Marcela Capcarova,
  • Radoslav Omelka

摘要

Background

Sea buckthorn (Elaeagnus rhamnoides (L.) A. Nelson) berry extract has been shown to favorably affect bone biomarkers in vitro, indicating its therapeutic potential. However, the effects of Elaeagnus rhamnoides (L.) A. Nelson on the skeletal system in diabetic individuals are unknown.

Methods

We provide the first evidence on the impact of Elaeagnus rhamnoides (L.) A. Nelson berries administered individually (500 and 1000 mg/kg/day for 3 months) and simultaneously with metformin (150 mg/kg/day for 3 months) on bone health in Zucker diabetic fatty (ZDF) rats, a suitable animal model of type 2 diabetes mellitus (T2DM). Biochemical and macroscopic analyses, microcomputed tomography, histological examination, and mechanical testing of bone were performed.

Results

Compared to untreated ZDF rats, ZDF rats co-administered with metformin and a higher dose of Elaeagnus rhamnoides (L.) A. Nelson showed reduced blood glucose and triglyceride levels, enhanced bone turnover markers, and improved several parameters of trabecular bone microarchitecture and matrix quality (p < 0.05). Minor positive effects on biochemical parameters and microstructural metrics of trabecular bone were noted in ZDF rats with concomitant administration of metformin and a lower dose of Elaeagnus rhamnoides (L.) A. Nelson (p < 0.05). ZDF rats given only the lower dose of Elaeagnus rhamnoides (L.) A. Nelson had decreased both glucose levels and the number of immature collagen fibers in trabecular bone (p < 0.05).

Conclusion

These findings demonstrate that combination therapy with Elaeagnus rhamnoides (L.) A. Nelson and metformin appears to be more effective in alleviating trabecular bone abnormalities associated with T2DM than monotherapy.