Scholarlink

<p>Bisphenol A (BPA), an industrial chemical absorbed through the intestines, can induce oxidative stress and inflammatory responses. Vitamin D (Vit D) has been widely investigated for its antioxidant and anti-inflammatory properties. In this experimental study, we aimed to evaluate the protective effects of Vit D against BPA-induced intestinal epithelial damage, inflammatory responses, and disruption of mucosal barrier integrity in rats. Fifty Wistar albino rats were divided into five groups: control (Co), olive oil (Oo), Vit D, BPA, and BPA + Vit D. Rats in the Vit D groups received 400 IU/day Vit D for 30 days, while BPA-treated groups received 25&#xa0;mg/kg/day BPA via gavage. The BPA + Vit D group showed significant reductions in MDA, TOS, and OSI levels compared with the BPA group (<i>P</i> &lt; 0.05), whereas Vit D administration increased GSH, TAS, SOD, and CAT levels (<i>P</i> &lt; 0.05). TNF-α and IL-6 levels were also significantly decreased in the BPA + Vit D group compared with the BPA group (<i>P</i> &lt; 0.05). CD68 immunohistochemistry revealed a disrupted and irregular distribution of CD68-positive macrophages within Peyer’s patches in the BPA group. These findings suggest that Vit D supplementation attenuates BPA-induced oxidative stress and inflammatory alterations in ileal tissue.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Protective Effects of Vit D Against BPA-induced Oxidative Stress and Inflammatory Alterations in Rat Ileal Peyer’s Patches

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月28日

查看全文
  • Tuğba Nur Deniz,
  • Emine Ümran Orscelik,
  • Feyza Başak,
  • Tansu Kuşat,
  • Yasemin Bicer,
  • Eyüp Altinoz

摘要

Bisphenol A (BPA), an industrial chemical absorbed through the intestines, can induce oxidative stress and inflammatory responses. Vitamin D (Vit D) has been widely investigated for its antioxidant and anti-inflammatory properties. In this experimental study, we aimed to evaluate the protective effects of Vit D against BPA-induced intestinal epithelial damage, inflammatory responses, and disruption of mucosal barrier integrity in rats. Fifty Wistar albino rats were divided into five groups: control (Co), olive oil (Oo), Vit D, BPA, and BPA + Vit D. Rats in the Vit D groups received 400 IU/day Vit D for 30 days, while BPA-treated groups received 25 mg/kg/day BPA via gavage. The BPA + Vit D group showed significant reductions in MDA, TOS, and OSI levels compared with the BPA group (P < 0.05), whereas Vit D administration increased GSH, TAS, SOD, and CAT levels (P < 0.05). TNF-α and IL-6 levels were also significantly decreased in the BPA + Vit D group compared with the BPA group (P < 0.05). CD68 immunohistochemistry revealed a disrupted and irregular distribution of CD68-positive macrophages within Peyer’s patches in the BPA group. These findings suggest that Vit D supplementation attenuates BPA-induced oxidative stress and inflammatory alterations in ileal tissue.

Graphical Abstract