Objectives <p>Inflammatory processes have an important role in the development of ED because they promote atherosclerosis and cause endothelial dysfunction. This study aimed to investigate the relationship between a new inflammatory marker, glucose/albumin ratio and ED and to compare it with inflammatory markers.</p> Methods <p>Data from 1651 patients diagnosed with ED between January 2020 and October 2024 were retrospectively reviewed, 205 people were included in the ED group and 198 people were included in the control group. Anthropometric measurements, comorbidities, metabolic and hormonal examinations of the groups were recorded. Glucose/albumin ratio (GAR) and CRP/albumin ratio (CAR) values were calculated in both groups, the cut-off value for the ratios was found, and the results were compared between the two groups.</p> Results <p>The GAR value was calculated as 26.52 ± 2.39 in the ED group and 22.35 ± 2.23 in the control group (<i>p</i> &lt; 0.001). The most appropriate cut-off value for this value was determined as 26.89 and it was seen that it had 42.5% sensitivity and 98.6% specificity. No significant difference was observed in GAR value among the ED subgroups (<i>p</i> = 0.182), but it was found to be higher in all subgroups compared to the control group (<i>p</i> &lt; 0.001). The AUC value was calculated as 0.898 in GAR and 0.747 in CAR, and the success was found to be higher in GAR.</p> Conclusion <p>Higher GAR values were observed in ED patients, but GAR should be regarded only as an exploratory measure rather than a validated biomarker.</p>