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<p>Atypical acute promyelocytic leukemia (aAPL) is a rare variant of acute myeloid leukemia (AML) defined by the lack of the typical <i>PML::RARA</i> fusion gene but instead involving alternative <i>RARs</i> rearrangements. Among these, the <i>STAT3::RARA</i> fusion has been identified, with all documented cases showing absolute resistance to ATRA treatment and associated with unfavorable prognosis. The <i>STAT3::RARA</i> fusion has been increasingly reported in recent years, indicating its recurrent nature. Recently, the identification of the tripartite <i>STAT3::RARA::TE</i> (TE, transposable element) fusion has provided insights into the molecular basis of ATRA resistance. Given these findings, an interim summary is timely.</p>

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Acute Promyelocytic Leukemia Harboring STAT3::RARA Fusion: Current Summary

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Zhan Su,
  • Haidong Zhu

摘要

Atypical acute promyelocytic leukemia (aAPL) is a rare variant of acute myeloid leukemia (AML) defined by the lack of the typical PML::RARA fusion gene but instead involving alternative RARs rearrangements. Among these, the STAT3::RARA fusion has been identified, with all documented cases showing absolute resistance to ATRA treatment and associated with unfavorable prognosis. The STAT3::RARA fusion has been increasingly reported in recent years, indicating its recurrent nature. Recently, the identification of the tripartite STAT3::RARA::TE (TE, transposable element) fusion has provided insights into the molecular basis of ATRA resistance. Given these findings, an interim summary is timely.