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Objectives <p>Prognostic nutritional index (PNI) and C-reactive protein to lymphocyte ratio (CLR) can predict disease severity and prognosis in critically ill patients. In this study, we aimed to evaluate the predictive value of inflammation-based scores, including the combination of baseline PNI and CLR, on disease severity and survival outcomes in patients with bloodstream infection (BSI).</p> Methods <p>82 patients who developed BSI were divided into two groups according to intensive care unit mortality: Survivors (n = 45) and Non-survivors (n = 37).</p> Results <p>When inflammatory scores were evaluated, it was observed that the PNI scores in Survivors were significantly high (9.0vs.6.0), the increase in the CLR rate was significant in Non-survivors (31.5vs.8.2) (p &lt; 0.05). There was a significant negative correlation between PNI and CLR (rho = −&#xa0;0.522, p &lt; 0.001). The disease severity distribution of the cases according to the PNI-CLR score groups was similar (p = 0.102). In multivariate analysis, a PNI-CLR score of 2 was an independent risk factor of mortality (OR:21.628, p = 0.001). The survival probability of patients with a PNI-CLR score of 2 was reduced compared to those with a low PNI-CLR score (p = 0.012,log-rank test).</p> Conclusion <p>Although the PNI-CLR score is not suggested for predicting disease severity, it was positively and independently associated with the prognosis of BSI.</p>

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Combined Prognostic Nutritional Index and C-Reactive Protein to Lymphocyte Ratio Predicts Prognosis in Patients with Bloodstream Infection

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月4日

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  • Aysegul Ilban,
  • Omur Ilban,
  • Nilay Tas

摘要

Objectives

Prognostic nutritional index (PNI) and C-reactive protein to lymphocyte ratio (CLR) can predict disease severity and prognosis in critically ill patients. In this study, we aimed to evaluate the predictive value of inflammation-based scores, including the combination of baseline PNI and CLR, on disease severity and survival outcomes in patients with bloodstream infection (BSI).

Methods

82 patients who developed BSI were divided into two groups according to intensive care unit mortality: Survivors (n = 45) and Non-survivors (n = 37).

Results

When inflammatory scores were evaluated, it was observed that the PNI scores in Survivors were significantly high (9.0vs.6.0), the increase in the CLR rate was significant in Non-survivors (31.5vs.8.2) (p < 0.05). There was a significant negative correlation between PNI and CLR (rho = − 0.522, p < 0.001). The disease severity distribution of the cases according to the PNI-CLR score groups was similar (p = 0.102). In multivariate analysis, a PNI-CLR score of 2 was an independent risk factor of mortality (OR:21.628, p = 0.001). The survival probability of patients with a PNI-CLR score of 2 was reduced compared to those with a low PNI-CLR score (p = 0.012,log-rank test).

Conclusion

Although the PNI-CLR score is not suggested for predicting disease severity, it was positively and independently associated with the prognosis of BSI.