<p>During the peri-implantation period, the embryo develops, the uterus acquires receptivity, and implantation and decidualization occur. Noc2l (NOC2-like nucleolar associated transcriptional repressor) was first discovered as an inhibitor of histone acetyltransferases (INHATs). Tumor suppressor protein p53 acts as an inhibitor of cellular growth. Our study aimed to determine the localization and expression of Noc2l and p53. According to our observations, Noc2l expression is higher than p53 expression in the luminal epithelium on the first day of pregnancy, coinciding with the onset of epithelial proliferation. The expression of Noc2l and p53 was found to be elevated in the lumen epithelium of the implantation sites on the fifth day of pregnancy, a period during which epithelial differentiation occurs. According to our immunohistochemistry results, Noc2l expression was low in the stroma of implantation sites on the sixth day of pregnancy, concurrent with decidua formation, while p53 expression was high. We found p53 expression higher in the stroma sites on the eighth day of pregnancy, after the secondary decidual site formed, than Noc2l expression. Results indicate a potential involvement of Noc2l and p53 in the processes of implantation and decidualization. Our evidence will serve as a roadmap for future investigations and may contribute to the elucidation of the underlying mechanisms of implantation failure and pregnancy loss. </p>