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Aim <p>Alkali-esophageal burn due to ingestion of corrosive substances is an important clinical entity that can be seen in all age groups, especially children. Chrysin is a natural flavonoid compound with a wide range of biological activities, including antioxidant, anti-inflammatory, antiapoptotic, and anticancer effects. This study aimed to ascertain the preventive efficacy of chrysin in the treatment of alkali-esophageal burns.</p> Materials and Methods <p>Rats were administered 0.2&#xa0;ml of 25% NaOH orally and CHR at 25 and 50&#xa0;mg/kg intraperitoneally for four days. The levels of oxidative stress, ER stress, inflammation, damage, and apoptotic and autophagic cell death in esophageal tissues were analyzed using biochemical and molecular methods. Additionally, esophageal tissue structure and function were examined using histological methods.</p> Results <p>Chrysin alleviated NaOH-induced increased oxidative stress by decreasing MDA and increasing antioxidants. Chrysin alleviated inflammation damage by inhibiting the NF-κB signaling pathway. Chrysin decreased apoptotic Caspase-3, and Bax and increased antiapoptotic Bcl-2. Moreover, Chrysin reduced autophagic death damage and ER stress damage. Chrysin facilitated the restoration of impaired structural integrity of esophageal tissue and increased Ki-67 and EGF levels, contributing to the healing process.</p> Conclusion <p>Chrysin exhibited antioxidant, antiapoptotic, anti-autophagic, anti-inflammatory, and anti-oxidant properties in alkali esophageal burns, as well as an effect on reducing ER stress injury. Additionally, chrysin facilitates esophageal tissue healing and maintains tissue integrity.</p> Graphical abstract <p></p>

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Chrysin Counteracts Sodium Hydroxide-Induced Alkali Esophageal Burn by Regulating Beclin-1/HO-1/NQO1, PERK/IRE1-α/ATF-6, Oxidative Stress, Inflammation, Apoptosis Signaling Pathways and Ki-67, EGF Expressions in Rats

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年4月14日

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  • Ayşe Betül Öztürk,
  • Hasan Şimşek,
  • Nurhan Akaras,
  • Fatih Mehmet Kandemir

摘要

Aim

Alkali-esophageal burn due to ingestion of corrosive substances is an important clinical entity that can be seen in all age groups, especially children. Chrysin is a natural flavonoid compound with a wide range of biological activities, including antioxidant, anti-inflammatory, antiapoptotic, and anticancer effects. This study aimed to ascertain the preventive efficacy of chrysin in the treatment of alkali-esophageal burns.

Materials and Methods

Rats were administered 0.2 ml of 25% NaOH orally and CHR at 25 and 50 mg/kg intraperitoneally for four days. The levels of oxidative stress, ER stress, inflammation, damage, and apoptotic and autophagic cell death in esophageal tissues were analyzed using biochemical and molecular methods. Additionally, esophageal tissue structure and function were examined using histological methods.

Results

Chrysin alleviated NaOH-induced increased oxidative stress by decreasing MDA and increasing antioxidants. Chrysin alleviated inflammation damage by inhibiting the NF-κB signaling pathway. Chrysin decreased apoptotic Caspase-3, and Bax and increased antiapoptotic Bcl-2. Moreover, Chrysin reduced autophagic death damage and ER stress damage. Chrysin facilitated the restoration of impaired structural integrity of esophageal tissue and increased Ki-67 and EGF levels, contributing to the healing process.

Conclusion

Chrysin exhibited antioxidant, antiapoptotic, anti-autophagic, anti-inflammatory, and anti-oxidant properties in alkali esophageal burns, as well as an effect on reducing ER stress injury. Additionally, chrysin facilitates esophageal tissue healing and maintains tissue integrity.

Graphical abstract