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Background <p>We aimed to investigate whether serum inflammatory parameters with indexes and the hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict the diagnosis and severity of disease in patients with hyperemesis gravidarum (HG).</p> Methods <p>This retrospective study evaluated 200 patients, including 47 patients with severe HG, 53 moderate HG cases, and 100 healthy pregnant controls. Laboratory parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index SII, the systemic inflammatory response index SIRI, the aggregated index of systemic inflammation AISI, and HALP score were calculated based on complete blood count parameters and compared between the groups.</p> Results <p>The PLR, NLR, MLR, SII, SIRI, and AISI values (&lt; 0.001, for all) in the HG group were significantly higher, and the HALP score was statistically significantly lower than in the control group (<i>p</i> &lt; 0.001). ROC analysis showed that NLR had the highest areas under the curve (AUC = 0.748), with a sensitivity of 70% and a specificity of 67% for the prediction of HG. Logistic regression analysis showed that NLR, MLR, PLR, SII, SIRI, AISI, and HALP scores were significant predictors of HG. In addition, PUQE scores correlated positively with length of hospital stay (<i>r</i> = 0,539, <i>p</i> &lt; 0.001).</p> Conclusions <p>NLR, MLR, PLR, SII, SIRI, and AISI were significantly higher in HG patients, while the HALP score was lower, but these were unrelated to disease severity. NLR was the best predictor among the indices.</p>

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Systemic Inflammatory Markers and HALP Score in Hyperemesis Gravidarum: Diagnostic and Prognostic Value

  • 期刊论文

  • 发表日期：

    2025年4月10日

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  • Özge Öztürk,
  • Recep Taha Ağaoğlu,
  • Seval Yılmaz Ergani,
  • Figen Günday,
  • Sena Küçükkayıkçı,
  • Kadriye Yakut Yücel

摘要

Background

We aimed to investigate whether serum inflammatory parameters with indexes and the hemoglobin, albumin, lymphocyte, and platelet (HALP) score predict the diagnosis and severity of disease in patients with hyperemesis gravidarum (HG).

Methods

This retrospective study evaluated 200 patients, including 47 patients with severe HG, 53 moderate HG cases, and 100 healthy pregnant controls. Laboratory parameters such as neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index SII, the systemic inflammatory response index SIRI, the aggregated index of systemic inflammation AISI, and HALP score were calculated based on complete blood count parameters and compared between the groups.

Results

The PLR, NLR, MLR, SII, SIRI, and AISI values (< 0.001, for all) in the HG group were significantly higher, and the HALP score was statistically significantly lower than in the control group (p < 0.001). ROC analysis showed that NLR had the highest areas under the curve (AUC = 0.748), with a sensitivity of 70% and a specificity of 67% for the prediction of HG. Logistic regression analysis showed that NLR, MLR, PLR, SII, SIRI, AISI, and HALP scores were significant predictors of HG. In addition, PUQE scores correlated positively with length of hospital stay (r = 0,539, p < 0.001).

Conclusions

NLR, MLR, PLR, SII, SIRI, and AISI were significantly higher in HG patients, while the HALP score was lower, but these were unrelated to disease severity. NLR was the best predictor among the indices.