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<p>A new schiff base sensor, <b>L1</b> ((4-((E)-1-(((E)-2-hydroxybenzylidene)hydrazono)ethyl)benzene-1,3-diol), was synthesized by the condensation of (E)-4-(1-hydrazonoethyl)benzene-1,3-diol and 2-hydroxybenzaldehyde. The interaction between the synthesized sensor <b>L1</b> and various metal ions was investigated employing ultraviolet–visible (UV–Vis) spectroscopy. The sensor displayed a 1:1 stoichiometric ratio with the Cu<sup>2</sup>⁺ ion, and the binding constant for the <b>L1</b>-Cu<sup>2</sup>⁺ complex was obtained as 0.4 × 10<sup>5</sup>&#xa0;M⁻<sup>1</sup>. Additionally, UV–Vis spectral variations in <b>L1</b> across a range of pH conditions demonstrated its efficacy over an extensive pH spectrum. The sensor facilitated the detection of Cu<sup>2</sup>⁺ ions in sub-second timeframes, with a limit of detection established at 32.2&#xa0;nM. Moreover, the recyclability of the sensor was assessed through the introduction of ethylenediaminetetraacetic acid (EDTA) to a solution containing the <b>L1</b>-Cu<sup>2</sup>⁺ complex. Density functional theory (DFT) simulations corroborated the 1:1 binding stoichiometry of the <b>L1</b>-Cu<sup>2</sup>⁺ complex, reinforcing its stability and suitability for cupric ion detection. Molecular docking studies elucidated substantial binding affinities of the synthesized Schiff base sensor <b>L1</b> with myoglobin, hemoglobin, bovine serum albumin (BSA), and human deoxyribonucleic acid (DNA), suggesting its potential applicability in biological systems. The practical effectiveness of the synthesized sensor for Cu<sup>2</sup>⁺ detection in authentic water samples was also substantiated.</p> Graphical Abstract <p></p>

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Detection of Cu2+ ions through colorimetric methods utilising a Schiff-base probe, along with its application in actual water samples and theoretical insights

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年11月9日

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  • Ram Kumar,
  • Bholey Singh,
  • Parveen Gahlyan,
  • Abhishek Verma,
  • Tanya Goel,
  • Rita Kakkar,
  • Balaram Pani

摘要

A new schiff base sensor, L1 ((4-((E)-1-(((E)-2-hydroxybenzylidene)hydrazono)ethyl)benzene-1,3-diol), was synthesized by the condensation of (E)-4-(1-hydrazonoethyl)benzene-1,3-diol and 2-hydroxybenzaldehyde. The interaction between the synthesized sensor L1 and various metal ions was investigated employing ultraviolet–visible (UV–Vis) spectroscopy. The sensor displayed a 1:1 stoichiometric ratio with the Cu2⁺ ion, and the binding constant for the L1-Cu2⁺ complex was obtained as 0.4 × 105 M⁻1. Additionally, UV–Vis spectral variations in L1 across a range of pH conditions demonstrated its efficacy over an extensive pH spectrum. The sensor facilitated the detection of Cu2⁺ ions in sub-second timeframes, with a limit of detection established at 32.2 nM. Moreover, the recyclability of the sensor was assessed through the introduction of ethylenediaminetetraacetic acid (EDTA) to a solution containing the L1-Cu2⁺ complex. Density functional theory (DFT) simulations corroborated the 1:1 binding stoichiometry of the L1-Cu2⁺ complex, reinforcing its stability and suitability for cupric ion detection. Molecular docking studies elucidated substantial binding affinities of the synthesized Schiff base sensor L1 with myoglobin, hemoglobin, bovine serum albumin (BSA), and human deoxyribonucleic acid (DNA), suggesting its potential applicability in biological systems. The practical effectiveness of the synthesized sensor for Cu2⁺ detection in authentic water samples was also substantiated.

Graphical Abstract