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<p>This study explores the antioxidant potential of deep eutectic solvent (DES) extracts from <i>Catharanthus roseus</i>, also known as Madagascar periwinkle. DESs, noted for their biodegradability, low toxicity, and cost-effectiveness, offer a promising green alternative for bioactive compound extraction. Evaluating the antioxidant activity of <i>C. roseus</i> leaves using DESs advances natural product chemistry by highlighting their efficiency. Antioxidant activity was measured with DPPH and hydroxyl radical scavenging assays, showing that DES extracts exhibited significant antioxidant effects. Among the solvents tested, methanol showed the highest antioxidant activity, with ChCl Acid DES closely following. These results underscore the effectiveness of DESs in extracting potent natural antioxidants from <i>C. roseus</i>, presenting a sustainable method for developing therapeutic agents against oxidative stress-related diseases. This study highlights DESs’ potential in improving extraction efficiency and promoting green chemistry practices in natural product extraction.</p>

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Deep eutectic solvents as eco-friendly agents for unlocking antioxidants from Catharanthus roseus

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年8月6日

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  • Parul Sharma,
  • Ramandeep Kaur,
  • Avjot Kaur

摘要

This study explores the antioxidant potential of deep eutectic solvent (DES) extracts from Catharanthus roseus, also known as Madagascar periwinkle. DESs, noted for their biodegradability, low toxicity, and cost-effectiveness, offer a promising green alternative for bioactive compound extraction. Evaluating the antioxidant activity of C. roseus leaves using DESs advances natural product chemistry by highlighting their efficiency. Antioxidant activity was measured with DPPH and hydroxyl radical scavenging assays, showing that DES extracts exhibited significant antioxidant effects. Among the solvents tested, methanol showed the highest antioxidant activity, with ChCl Acid DES closely following. These results underscore the effectiveness of DESs in extracting potent natural antioxidants from C. roseus, presenting a sustainable method for developing therapeutic agents against oxidative stress-related diseases. This study highlights DESs’ potential in improving extraction efficiency and promoting green chemistry practices in natural product extraction.