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<p>Amino acids (AAs) play crucial roles in metabolism, neurotransmission, cellular signalling, and disease progression, making their accurate detection essential in clinical diagnostics, food safety, pharmaceutical analysis, and environmental monitoring. Conventional analytical techniques such as chromatography, mass spectrometry, and spectrophotometry, although highly accurate, are often limited by high cost, complex sample preparation, and lack of portability. In recent years, electrochemical biosensors have emerged as powerful alternatives, offering high sensitivity, rapid response, low cost, and suitability for point-of-care applications. This review critically examines recent advances in electrochemical biosensors for AA estimation, with a particular focus on nanomaterial-modified electrodes and molecularly imprinted systems. The integration of nanomaterials including metal nanoparticles (NPs), metal oxides, carbon-based materials, and nanocomposites has significantly enhanced sensor performance by improving electron transfer, surface area, stability, and selectivity. Recent strategies for detecting key AAs such as tryptophan, tyrosine, lysine, methionine, and glycine are discussed, along with their analytical performance and real-sample applications.</p>

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Recent developments in nanomaterial modified electrodes for amino acid sensing

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年7月1日

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  • Ananta Bisht,
  • Anam Fatima,
  • Jyoti Maheshwari,
  • Abhishek Dusad,
  • Arun Bughani,
  • M. G. H. Zaidi,
  • Sameena Mehtab

摘要

Amino acids (AAs) play crucial roles in metabolism, neurotransmission, cellular signalling, and disease progression, making their accurate detection essential in clinical diagnostics, food safety, pharmaceutical analysis, and environmental monitoring. Conventional analytical techniques such as chromatography, mass spectrometry, and spectrophotometry, although highly accurate, are often limited by high cost, complex sample preparation, and lack of portability. In recent years, electrochemical biosensors have emerged as powerful alternatives, offering high sensitivity, rapid response, low cost, and suitability for point-of-care applications. This review critically examines recent advances in electrochemical biosensors for AA estimation, with a particular focus on nanomaterial-modified electrodes and molecularly imprinted systems. The integration of nanomaterials including metal nanoparticles (NPs), metal oxides, carbon-based materials, and nanocomposites has significantly enhanced sensor performance by improving electron transfer, surface area, stability, and selectivity. Recent strategies for detecting key AAs such as tryptophan, tyrosine, lysine, methionine, and glycine are discussed, along with their analytical performance and real-sample applications.